Tobias Bauer

Tobias Bauer


Tobias Bauer studied chemistry at JGU Mainz and University of Toronto and graduated in 2017 (M.Sc.). His current research as a doctoral candidate is focused on the analysis of the secondary structure-driven self-assembly of polypept(o)ides with the aim to independently adjust morphology and (core-) functionality for the stimuli-responsive release of multiple (pro-) drugs.


Institut für Organische Chemie
Johannes Gutenberg-Universität Mainz
Duesbergweg 10-14
55128 Mainz  

+49 6131 39 25468

Research topic

From Novel Concepts for Directed Self-Assembly of Polypept(o)ides to Combination Therapies


Targeting Cancer Chemotherapy Resistance by Precision Medicine-Driven Nanoparticle-Formulated Cisplatin

Svenja Siemer, Tobias A. Bauer, Paul Scholz, Christina Breder, Federico Fenaroli, Gregory Harms, Dimo Dietrich, Jörn Dietrich, Christine Rosenauer, Matthias Barz, Sven Becker, Sebastian Strieth, Christoph Reinhardt, Torsten Fauth, Jan Hagemann, Roland H. Stauber

ACS Nano, 2021, 15, 11, 18541-18556









Photocleavable core cross-linked polymeric micelles of polypept(o)ides and ruthenium(II) complexes

Tobias A. Bauer, Jonas Eckrich, Nadine Wiesmann, Felix Kuczelinis, Wen Sun, Xiaolong Zeng, Benjamin Weber, Si Wu, Nicolas Herbert Bings, Sebastian Strieth, Matthias Barz

J. Mater. Chem. B., 2021, Advanced Article







Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages

Tobias A. Bauer, Natalie K. Horvat, Oriana Marques, Sara Chocarro, Christina Mertens, Silvia Colucci, Sascha Schmitt, Luca M. Carrella, Svenja Morsbach, Kaloian Koynov, Federico Fenaroli, Peter Blümler, Michaela Jung, Rocio Sotillo, Matthias W. Hentze, Martina U. Muckenthaler, Matthias Barz

Adv. Healthcare Mater., 2021, 2100385



Secondary Structure-Driven Self-Assembly of Thiol-Reactive Polypept(o)ides

Tobias A. Bauer, Jan Imschweiler, Christian Muhl, Benjamin Weber, Matthias Barz

Biomacromolecules, 2021, 22, 5, 2171-2180

DOI: https://doi.org10.1021/acs.biomac.1c00253


Racemic S-(ethylsulfonyl)-DL-cysteine N-Carboxyanhydrides Improve Chain Lengths and Monomer Conversion for β-Sheet-Controlled Ring-Opening Polymerization

Tobias A. Bauer, Christian Muhl, Dieter Schollmeyer, Matthias Barz

Macromol. Rapid Commun., 2020, 2000470



Tetrazine- and trans-cyclooctene-functionalised polypept(o)ides for fast bioorthogonal tetrazine ligation

Kerstin Johann, Dennis Svatunek, Christine Seidl, Silvia Rizzelli, Tobias A. Bauer, Lydia Braun, Kaloian Koynov, Hannes Mikula and Matthias Barz

Polym. Chem., 2020, Advanced Article



Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle–Cell Interactions

Nils-Jørgen Knudsen Dal, Agnese Kocere, Jens Wohlmann, Simon Van Herck, Tobias A. Bauer, Julien Resseguier, Shahla Bagherifam, Hilde Hyldmo, Matthias Barz, Bruno G. De Geest, Federico Fenaroli

Small, 2020, 1906719



Core‐Shell Functionalized Zirconium‐Pemetrexed Coordination Nanoparticles as Carriers with a High Drug Content

Benjamin Steinborn, Patrick Hirschle, Miriam Höhn, Tobias Bauer, Matthias Barz, Stefan Wuttke, Ernst Wagner, Ulrich Lächelt

Advanced Therapeutics, 2019, 1900120

DOI: /


Coordinative Binding of Polymers to Metal–Organic Framework Nanoparticles for Control of Interactions at the Biointerface

Andreas ZimpelNader Al DanafBenjamin SteinbornJasmin KuhnMiriam HöhnTobias Bauer§Patrick HirschleWaldemar SchrimpfHanna EngelkeErnst Wagner Matthias Barz§ Don C. LambUlrich Lächelt, and Stefan Wuttke

ACS Nano, Article ASAP  DOI: 10.1021/acsnano.8b06287

Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers

Regina Holm, Marcel Douverne, Benjamin Weber, Tobias Bauer, Andreas Best, Patrick Ahlers, Kaloian Koynov, Pol Besenius and Matthias Barz

Biomacromolecules, 2018, in press. DOI: 10.1021/acs.biomac.8b01545

Poly(S-ethylsulfonyl-l-homocysteine): An α-Helical Polypeptide for Chemoselective Disulfide Formation

Christian MuhlOlga SchäferTobias BauerHans-Joachim Räder and Matthias Barz

Macromolecules 201851 (20), 8188–8196, DOI: 10.1021/acs.macromol.8b01442

Secondary Structure-Driven Hydrogelation using Foldable Telechelic Polymer-Peptide Conjugates

R. Otter, N.A. Henke, C. Berac, T. Bauer, M. Barz, S. Seiffert, P. Besenius

Macromol. Rapid Commun. 2018, 39, (17), 1800459. DOI: 10.1002/marc.201800459


Kinetically Controlled Stepwise Self-Assembly of Au(I)-Metallopeptides in Water

B. Kemper, L. Zengerling, D. Spitzer, R. Otter, T. Bauer, P. Besenius

J. Am. Chem. Soc. 2018140, 534-537. DOI: 10.1021/jacs.7b08189


Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures

Kristina Klinker ,Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz

Angew. Chem. Int. Ed. 201756, 9608–9613.

DOI: 10.1002/anie.201702624

Functionalization of P3HT with Various Mono- and Multidentate Anchor Groups

F. Menk*, A. Fokina*, B. Oschmann*, T.Bauer*, Y.Nyquist, L.Braun, J. Kiehl, R. Zentel

Journal of the Brazilian Chemical Society201700 (00), 1-10. DOI:

*equal author contribution