Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

E. Johanna L. Stéen, Jesper T. Jørgensen, Kerstin Johann, Kamilla Nørregaard, Barbara Sohr, Dennis Svatunek, Alexander Birke, Vladimir Shalgunov, Patricia E. Edem, Raffaella Rossin, Christine Seidl, Friederike Schmid, Marc S. Robillard, Jesper L. Kristensen, Hannes Mikula, Matthias Barz, Andreas Kjær, Matthias M. Herth

ACS Nano 2020, 14, 1, 568-584



Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle–Cell Interactions

Nils-Jørgen Knudsen Dal, Agnese Kocere, Jens Wohlmann, Simon Van Herck, Tobias A. Bauer, Julien Resseguier, Shahla Bagherifam, Hilde Hyldmo, Matthias Barz, Bruno G. De Geest, Federico Fenaroli

Small, 2020, 1906719



Poly(Sarcosine) Surface Modification Imparts Stealth-Like Properties to Liposomes

Stefan Bleher, Jonas Buck, Christian Muhl, Sandro Sieber, Sabine Barnert, Dominik Witzigmann, Jörg Huwyler, Matthias Barz, Regine Süss

Small, 2019, 1904716


Facile synthesis of amphiphilic AB3 and A3B miktoarm PeptoMiktoStars

David Schwiertz, Regina Holm, Matthias Barz

Polymer Journal, 52, 119-132 (2020)



Trendbericht Makromolekulare Chemie

Markus Gallei, Bernhard Schmidt, Matthias Barz

Nachrichten aus der Chemie, 2019, 67 (10), 40-49


Core‐Shell Functionalized Zirconium‐Pemetrexed Coordination Nanoparticles as Carriers with a High Drug Content

Benjamin Steinborn, Patrick Hirschle, Miriam Höhn, Tobias Bauer, Matthias Barz, Stefan Wuttke, Ernst Wagner, Ulrich Lächelt

Advanced Therapeutics, 2019, 1900120

DOI: /

Synthesis and characterization of bisalkylated polysarcosine-based lipopolymers

Christian Muhl, Marcus Conrad, Dennis Unthan, Matthias Barz

European Polymer Journal, 2019, 120, 109223

DOI: //

Multifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential

Regina Holm, David Schwiertz, Benjamin Weber, Jennifer Schultze, Jasmin Kuhn, Kaloian Koynov, Ulrich Lächelt, Matthias Barz

Macromolecular Bioscience, 2019, 1900152

DOI: //

Interactions Between Blood Proteins and Nanoparticles Investigated Using Molecular Dynamics Simulations

Timo Schafer, Christian Muhl, Matthias Barz, Friederike Schmid, Giovanni Settanni

In: W. Nagel, D. Kröner, M. Resch, High Performance Computing in Science and Engineering ' 18. Springer, Cham (2019)

DOI: /10.1007/978-3-030-13325-2_4

Ligand density on nanoparticles: A parameter with critical impact on nanomedicine

Alaaldin M. Alkilany, Lin Zhu, Horst Weller, Alf Mews, Wolfgang J. Parak, Matthias Barz, Neus Feliu

In Press DOI: /10.1016/j.addr.2019.05.010

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics

Svenja Siemer1, Dana Westmeier1, Matthias Barz, Jonas Eckrich, Désirée Wünsch, Christof Seckert, Christian Thyssen, Oliver Schilling, Mike Hasenberg, Chengfang Pang, Dominic Doctor, Shirley K. Knauer, Roland H. Stauber, Sebastian Strieth

Biomaterials, 2019, 192, 551-559   DOI: /10.1016/j.biomaterials.2018.11.028

Coordinative Binding of Polymers to Metal–Organic Framework Nanoparticles for Control of Interactions at the Biointerface

Andreas ZimpelNader Al DanafBenjamin SteinbornJasmin KuhnMiriam HöhnTobias Bauer§Patrick HirschleWaldemar SchrimpfHanna EngelkeErnst Wagner Matthias Barz§ Don C. LambUlrich Lächelt, and Stefan Wuttke

ACS Nano, 2019, 13, 4, 3884-3895  DOI: 10.1021/acsnano.8b06287

Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy

Inka Negwer, Andreas Best, Meike Schinnerer, Olga Schäfer, Leon Capeloa, Manfred Wagner, Manfred Schmidt, Volker Mailänder, Mark Helm, Matthias Barz, Hans-Jürgen Butt & Kaloian Koynov

Nature Communications, 2018, 9, 5306 DOI:

Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization

Olga Schäfer, Dieter Schollmeyer, Alexander Birke, Regina Holm, Kerstin Johann, Christian Muhl, Christine Seidl, Benjamin Weber, Matthias Barz

Tetrahedron Letters, 2018, 60, (3), 272-275


Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers

Regina Holm, Marcel Douverne, Benjamin Weber, Tobias Bauer, Andreas Best, Patrick Ahlers, Kaloian Koynov, Pol Besenius and Matthias Barz

Biomacromolecules, 2019, 20, (1), 375-388 DOI: 10.1021/acs.biomac.8b01545

Poly-Sarcosine and Poly(ethylene-glycol) interactions with proteins investigated using molecular dynamics simulations

Giovanni SettanniTimo SchäferChristian Muhl, Matthias Barz and Friederike Schmid

Computional and Structural Biotechnology Journal, 2018, 16, 543-550. DOI:10.1016/j.csbj.2018.10.012

Poly(S-ethylsulfonyl-l-homocysteine): An α-Helical Polypeptide for Chemoselective Disulfide Formation

Christian MuhlOlga SchäferTobias BauerHans-Joachim Räder, and Matthias Barz

Macromolecules 2018, 51, (20), 8188-8196 DOI: 10.1021/acs.macromol.8b01442

Secondary Structure-Driven Hydrogelation using Foldable Telechelic Polymer-Peptide Conjugates

R. Otter, N.A. Henke, C. Berac, T. Bauer, M. Barz, S. Seiffert, P. Besenius

Macromol. Rapid Commun. 2018, 39, (17), 1800459. DOI: 10.1002/marc.201800459

Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models

Federico FenaroliUrska RepnikYitian XuKerstin JohannSimon Van HerckPradip DeyFrode Miltzov SkjeldalDominik M. FreiShahla BagherifamAgnese KocereRainer HaagBruno G. De GeestMatthias BarzDavid G. Russell, and Gareth Griffiths

ACS Nano201812 (8), pp 8646–8661. DOI: 10.1021/acsnano.8b04433

Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors

Benjamin TheekMaike BauesFelix Gremse, Robert Pola, Michal PecharInka NegwerKaloian KoynovBenjamin Weber, Matthias Barz, Willi Jahnen-Dechent, Gert Storm, Fabian Kiessling, TwanLammers

Journal of Controlled Release, 2018DOI:10.1016/j.jconrel.2018.05.002

Site-Specific DBCO Modification of DEC205 Antibody for Polymer Conjugation

Simone Beck, Jennifer Schultze, Hans-Joachim Räder, Regina Holm, Meike Schinnerer, Matthias Barz, Kaloian Koynov and Rudolf Zentel

Polymers 201810(2), 141; doi:10.3390/polym10020141

Cooperative Catechol-Functionalized Polypept(o)ide Brushes and Ag Nanoparticles for Combination of Protein Resistance and Antimicrobial Activity on Metal Oxide Surfaces

Jin YooAlexander BirkeJoonwon KimYeongseon JangSeuk Young SongSeungmi RyuByung-Soo KimByung-Gee KimMatthias Barz, and Kookheon Char

Biomacromolecules, 2018, DOI: 10.1021/acs.biomac.8b00135

Of Thiols and Disulfides: Methods for Chemoselective Formation of Asymmetric Disulfides in Synthetic Peptides and Polymers

Olga Schäfer and Matthias Barz

Chem. Eur. J., 2018, DOI: 10.1002/chem.201800681

Solution Properties of Polysarcosine: From Absolute and Relative Molar Mass Determinations to Complement Activation

Benjamin Weber, Alexander Birke, Karl Fischer, Manfred Schmidt, and Matthias Barz

Macromolecules, 2018, DOI: 10.1021/acs.macromol.8b00258

Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications

Progress in Polymer Science, 2018, in press.

Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell

Chemical Communications, 2018, 54, 401-404. DOI:10.1039/C7CC08127H

From Polymers to Functional Biomaterials

Tanja Weil, Matthias Barz

Macromolecular Bioscience 2017DOI: 10.1002/mabi.201700307

Combining Orthogonal Reactive Groups in Block Copolymers for Functional Nanoparticle Synthesis in a Single Step

Olga Schäfer, Kristina Klinker, Lydia Braun, David Huesmann, Jennifer Schultze, Kaloian Koynov, and Matthias Barz

DOI: 10.1021/acsmacrolett.7b00678

Immunomodulatory Therapy of Inflammatory Liver Disease Using Selectin-Binding Glycopolymers

Matthias Bartneck, Christopher T. Schloßer, Matthias Barz, Rudolf Zentel, Christian Trautwein, Twan Lammers, Frank Tacke

ACS Nano 2017, DOI: 10.1021/acsnano.7b04630



PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes

Benjamin Weber, Cinja Kappel, Martin Scherer, Mark Helm, Matthias Bros, Stephan Grabbe, Matthias Barz

Macromol. Biosci. 2017, 1700061. DOI: 10.1002/mabi.201700061

Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines

Philipp Heller, Dominika Hobernik, Ulrich Lächelt, Meike Schinnerer, Benjamin Weber, Manfred Schmidt, Ernst Wagner, Matthias Bros, Matthias Barz

Journal of Controlled Release 2017, 258, 146–160. DOI: 10.1016/j.jconrel.2017.05.012

Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers

Yoanna Tsvetkova, Nataliia Beztsinna, Maike Baues, Dionne Klein, Anne Rix, Susanne K. Golombek, Wa’el Al Rawashdeh, Felix Gremse, Matthias Barz, Kaloian Koynov, Srinivas Banala, Wiltrud Lederle, Twan Lammers, Fabian Kiessling

Nano Lett. 2017, 17, 4665−4674. DOI: 10.1021/acs.nanolett.7b01171

Tuning the pH-Switch of Supramolecular Polymer Carriers for siRNA to Physiologically Relevant pH

Patrick Ahlers, Hendrik Frisch, Regina Holm, Daniel Spitzer, Matthias Barz, Pol Besenius

Macromol. Biosci. 2017, 1700111. DOI: 10.1002/mabi.201700111

Programmable Assembly of Peptide Amphiphile via Noncovalent-to- Covalent Bond Conversion

Kohei Sato, Wei Ji, Liam C. Palmer, Benjamin Weber, Matthias Barz, Samuel I. Stupp

  1. Am. Chem. Soc. 2017, 139, 8995−9000. DOI: 10.1021/jacs.7b03878

Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures

Kristina Klinker ,Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz

Angew. Chem. Int. Ed. 2017, 56, 9608–9613.

DOI: 10.1002/anie.201702624

Sekundärstrukturbildung als Triebkraft für die Selbstorganisation reaktiver Polypept(o)ide: Steuerung von Größe, Form und Funktion kernvernetzter Nanostrukturen

Kristina Klinker, Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz

Angew. Chem. 2017 , 129, 9737–9742. DOI: 10.1002/ange.201702624

Influence of Block Ionomer Microstructure on Polyplex Properties: Can Simulations Help to Understand Differences in Transfection Efficiency?

Philipp Heller, Jiajia Zhou, Benjamin Weber, Dominika Hobernik, Matthias Bros, Friederike Schmid, Matthias Barz

Small 2017, 13, 1603694. DOI: 10.1002/smll.201603694

Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles

Matthias Bartneck, Ulf Panzer, Robert Pola, Michal Pechar, Gert Storm,

Nicole Mohr, Matthias Barz, Rudolf Zentel, Fabian Kiessling, Christian Trautwein, Twan Lammers, Frank Tacke

Biomaterials, 2017, 114, 106e120

Synthesis and Characterization of  Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars

Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber, Matthias Barz

Macromol. Biosci. 2017, 17, 1600514. DOI: 10.1002/mabi.201600514

Polymeric Selectin Ligands Mimicking Complex Carbohydrates: FromSelectin Binders to Modifiers of Macrophage Migration

Kai E. Moog, Matthias Barz, Matthias Bartneck, Figen Beceren-Braun, Nicole Mohr, Zhuojun Wu, Lydia Braun, Jens Dernedde, Elisa A. Liehn, Frank Tacke, Twan Lammers, Horst Kunz, Rudolf Zentel

Angew. Chem. Int. Ed. 2017, 56, 1416–1421.

DOI: 10.1002/anie.201610395

Polymere Selectinliganden als komplexe Glykomimetika: von Selectinbindung bis zur Modifizierung der Makrophagenmigration

Kai E. Moog, Matthias Barz, Matthias Bartneck, Figen Beceren-Braun, Nicole Mohr, Zhuojun Wu, Lydia Braun, Jens Dernedde, Elisa A. Liehn, Frank Tacke, Twan Lammers, Horst Kunz, Rudolf Zentel

Angew.Chem. 2017, 129,1438–1443. DOI: 10.1002/ange.201610395

Orthogonally reactive amino acids and end groups in NCA polymerization

David Huesmann, Kristina Klinker, Matthias Barz

Polym. Chem. 2017, 8, 957–971. DOI: 10.1039/C6PY01817C

Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications

Qizhi Hu, Cristianne J.F. Rijcken, Ethlinn van Gaal, Paul Brundel, Hana Kostkova, Tomas Etrych, Benjamin Weber, Matthias Barz, Fabian Kiessling, Jai Prakash, Gert Storm, Wim E. Hennink, Twan Lammers

Journal of Controlled Release 2016, 244, 314–325.

Rethinking Cysteine Protective Groups: S-Alkylsulfonyl-l-Cysteines for Chemoselective Disulfide Formation

Olga Schäfer, David Huesmann, Christian Muhl, Matthias Barz

Chem. Eur. J. 2016, 22, 18085 –18091. DOI: 10.1002/chem.201604391

Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers

Benjamin Weber, Christine Seidl, David Schwiertz, Martin Scherer, Stefan Bleher, Regine Süss, Matthias Barz

Polymers 2016, 8, 427-440. DOI: 10.3390/polym8120427

Poly(S-ethylsulfonyl-l-cysteines) for Chemoselective Disulfide Formation

Olga Schäfer, David Huesmann, Matthias Barz

Macromolecules 2016, 49, 8146–8153. DOI: 10.1021/acs.macromol.6b02064

Nanoparticles and the immune system: challenges and opportunities

Stephan Grabbe, Katharina Landfester, Detlef Schuppan, Matthias Barz Rudolf Zentel

Nanomedicine 2016, 11, 2621-2624. DOI: 10.2217/nnm-2016-0281

Multidentate Polysarcosine-Based Ligands for Water-Soluble Quantum Dots

Ana Fokina, Kristina Klinker, Lydia Braun, Byeong Guk Jeong, Wan Ki Bae, Matthias Barz, Rudolf Zentel

Macromolecules 2016, 49, 3663−3671.

DOI: 10.1021/acs.macromol.6b00582

Complex formation between polyelectrolytes and oppositely charged oligoelectrolytes

Jiajia Zhou, Matthias Barz, Friederike Schmid

The Journal of Chemical Physics 2016, 144, 164902.

DOI: 10.1063/1.4947255

Exploring new activating groups for reactive cysteine NCAs

David Huesmann, Olga Schäfer, Lydia Braun, Kristina Klinker, Thomas Reuter, Matthias Barz

Tetrahedron Letters, 2016, 57, 1138–1142.

DOI: 10.1016/j.tetlet.2016.01.104

Bioreducible Poly-l-Lysine–Poly[HPMA] Block Copolymers Obtained by RAFT-Polymerization as Efficient Polyplex-Transfection Reagents

Kristof Tappertzhofen, Simone Beck, Evelyn Montermann, David Huesmann, Matthias Barz, Kaloian Koynov, Matthias Bros, Rudolf Zentel

Macromol. Biosci. 2016, 16, 106–120. DOI: 10.1002/mabi.201500212

Synthesis of Amphiphilic Block Copolypept(o)ides by Bifunctional Initiators: Making PeptoMicelles Redox Sensitive

Regina Holm, Kristina Klinker, Benjamin Weber, Matthias Barz

Macromol. Rapid Commun. 2015, 36, 2083−2091.

DOI: 10.1002/marc.201500402

Polypept(o)ides: Hybrid Systems Based on Polypeptides and Polypeptoids

Kristina Klinker, Matthias Barz

Macromol. Rapid Commun. 2015, 36, 1943−1957.

DOI: 10.1002/marc.201500403

Complexity and simplification in the development of nanomedicines

Matthias Barz

Nanomedicine 2015, 10, 3093–3097. DOI: 10.2217/nnm.15.146

Well-defined carbohydrate-based polymers in calcium carbonate crystallization: Influence of stereochemistry in the polymer side chain on polymorphism and morphology

Matthias Barz, Sebastian Götze, Niklas Loges, Timo Schüler, Patrick Theato, Wolfgang Tremel, Rudolf Zentel

European Polymer Journal, 2015, 69, 628–635.

DOI: 10.1016/j.eurpolymj.2015.02.010

A head-to-head comparison of poly(sarcosine) and poly(ethylene glycol) in peptidic, amphiphilic block copolymers

David Huesmann, Adrian Sevenich, Benjamin Weber, Matthias Barz
Polymer 2015, 67, 240-248. DOI: 10.1016/j.polymer.2015.04.070

Cylindrical Brush Polymers with Polysarcosine Side Chains: A Novel Biocompatible Carrier for Biomedical Applications

Christian Hörtz, Alexander Birke, Leonard Kaps, Sandra Decker, Eva Wächtersbach, Karl Fischer, Detlef Schuppan, Matthias Barz, Manfred Schmidt

Macromolecules 2015, 48, 2074−2086. DOI: 10.1021/ma502497x

Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation

Marina Talelli, Matthias Barz, Cristianne J. F. Rijcken, Fabian Kiessling, Wim E. Hennink, Twan Lammers

Nano Today 2015, 10, 93–117. DOI: 10.1016/j.nantod.2015.01.005

Evaluating chemical ligation techniques for the synthesis of block copolypeptides, polypeptoids and block copolypept(o)ides: a comparative study

Kristina Klinker, Regina Holm, Philipp Heller, Matthias Barz

Polym. Chem. 2015, 6, 4612–4623. DOI: 10.1039/c5py00461f

Directed Interactions of Block Copolypept(o)ides with Mannose-Binding Receptors:PeptoMicelles Targeted to Cells of the InnateImmune System

Philipp Heller, Nicole Mohr, Alexander Birke, Benjamin Weber, Angelika Reske-Kunz, Matthias Bros, Matthias Barz

Macromol. Biosci. 2015, 15, 63–73. DOI: 10.1002/mabi.201400417

Synthesis and Sequential Deprotection of Triblock Copoly-pept(o)ides Using Orthogonal Protective Group Chemistry

Philipp Heller, Benjamin Weber, Alexander Birke, Matthias Barz

Macromol. Rapid Commun. 2015, 36, 38−44.

DOI: 10.1002/marc.201400466

18F-Radiolabeling, Preliminary Evaluation of Folate-pHPMA Conjugates via PET

Hanno Schieferstein, Annette Kelsch, Achim Reibel, Kaloian Koynov,Matthias Barz, Hans-Georg Buchholz, Nicole Bausbacher, Oliver Thews, Rudolf Zentel, Tobias L. Ross

Macromol. Biosci. 2014, 14, 1396–1405. DOI: 10.1002/mabi.201400200

From Polymers to Nanomedicines: New Materials for Future Vaccines

Philipp Heller, David Huesmann, Martin Scherer, Matthias Barz

 Molecular Vaccines. Springer, Cham. 2014, 643–671. DOI:10.1007/978-3-319-00978-0_15

Quo Vadis Nanomedicine

Robert Luxenhofer, Matthias Barz, Michael Schillmeier

Nanomedicine 2014, 9, 2083-2086. DOI: org/10.2217/nnm.14.140

Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells

Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros, Matthias Barz

Macromol. Biosci. 2014, 14, 1380–1395. DOI: 10.1002/mabi.201400167

A Deeper Insight into the Postpolymerization Modification of Polypenta Fluorophenyl Methacrylates to Poly( N -(2-Hydroxy-propyl) Methacrylamide)

Nicole Mohr, Matthias Barz, Romina Forst, Rudolf Zentel

Macromol. Rapid Commun. 2014, 35, 1522−1527.

DOI: 10.1002/marc.201400249

New Perspectives of HPMA-based Copolymers Derived by Post-Polymerization Modification

Lutz Nuhn, Matthias Barz, Rudolf Zentel

Macromol. Biosci. 2014, 14, 607–618. DOI: 10.1002/mabi.201400028

Revisiting Secondary Structures in NCA Polymerization: Influences on the Analysis of Protected Polylysines

David Huesmann, Alexander Birke, Kristina Klinker, Stephan Türk, Hans Joachim Räder, Matthias Barz

Macromolecules 2014, 47, 928−936. DOI: 10.1021/ma5000392

Polypeptoid-block-polypeptide Copolymers: Synthesis, Characterization, and Application of Amphiphilic Block Copolypept(o)ides in Drug Formulations and Miniemulsion Techniques

Alexander Birke, David Huesmann, Annette Kelsch, Martin Weilbächer, Jing Xie, Matthias Bros, Tobias Bopp, Christian Becker, Katharina Landfester, Matthias Barz

Biomacromolecules 2014, 15, 548−557. DOI: 10.1021/bm401542z

Interaction of N-(2-hydroxypropyl) methacrylamide based homo, random and block copolymers with primary immune cells

Martin Weilbächer, Mareli Allmeroth, Mirjam Hemmelmann, Sandra Ritz, Volker Mailänder, Tobias Bopp, Matthias Barz, Rudolf Zentel, Christian Becker

Journal of Biomedical Nanotechnology 2014, 10, 81-91.

DOI: 10.1166/jbn.2014.1693

PAA-PAMPS Copolymers as an Efficient Tool to Control CaCO3 Scale Formation

Michael Dietzsch, Matthias Barz,  Timo Schüler,  Stefanie Klassen, Martin Schreiber, Moritz Susewind, Niklas Loges, Michael Lang, Nadja Hellmann, Monika Fritz, Karl Fischer, Patrick Theato, Angelika Kühnle, Manfred Schmidt, Rudolf Zentel, Wolfgang Tremel

Langmuir 2013, 29, 3080−3088. DOI: 10.1021/la4000044

Synthesis of Maleimide-Functionalyzed HPMA-Copolymers and in vitro Characterization of the aRAGE- and Human Immunoglobulin(huIgG)–Polymer Conjugates

Kristof Tappertzhofen, Verena V. Metz, Mario Hubo, Matthias Barz, Rolf Postina, Helmut Jonuleit, Rudolf Zentel

Macromol. Biosci. 2013, 13, 203–214. DOI: 10.1002/mabi.201200344

A versatile post-polymerization modification method for polyglutamic acid: synthesis of orthogonal reactive polyglutamates and their use in “click chemistry”

Matthias Barz, Aroa Duro-Castano, Maria J. Vicent

Polym. Chem. 2013, 4, 2989-2994. DOI: 10.1039/c3py00189j

A controlled and versatile NCA polymerization method for the synthesis of polypeptides

Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz, María J. Vicent

Polym. Chem. 2013, 4, 3182-3186. DOI: 10.1039/c3py00347g

HPMA Copolymers as Surfactants in the Preparation of Biocompatible Nanoparticles for Biomedical Application

Annette Kelsch, Stephanie Tomcin, Kristin Rausch, Matthias Barz, Volker Mailänder, Manfred Schmidt, Katharina Landfester, Rudolf Zentel

Biomacromolecules 2012, 13, 4179−4187. DOI: 10.1021/bm301453g

P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency

Matthias Barz, Ana Armiñán, Fabiana Canal, Florian Wolf, Kaloian Koynov, Holger Frey, Rudolf Zentel, María J. Vicent

Journal of Controlled Release 2012, 163, 63–74.

DOI: 10.1016/j.jconrel.2012.05.024

CpG-DNA loaded multifunctional MnO nanoshuttles for TLR9-specific cellular cargo delivery, selective immune-activation and MRI

Mohammed I. Shukoor, Filipe Natalio, Muhammad N. Tahir, Matthias Barz, Stefan Weber, Christoph Brochhausen, Rudolf Zentel, Laura M. Schreiber, Jürgen Briegere, Wolfgang Tremel

  1. Mater. Chem. 2012, 22, 8826-8834. DOI: 10.1039/c2jm16903g

DOI: 10.1021/acs.macromol.6b00582

HPMA Based Amphiphilic Copolymers Mediate Central Nervous Effects of Domperidone

Mirjam Hemmelmann, Christiane Knoth, Ulrich Schmitt, Mareli Allmeroth, Dorothea Moderegger, Matthias Barz, Kaloian Koynov, Christoph Hiemke, Frank Rösch, Rudolf Zentel

Macromol. Rapid Commun. 2011, 32, 712–717.

DOI: 10.1002/marc.201000810

Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

Matthias Barz, Robert Luxenhofer, Rudolf Zentel, María J. Vicent  

Polym. Chem. 2011, 2, 1900-1918. DOI: 10.1039/C0PY00406E

72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging

Matthias M. Herth, Matthias Barz, Markus Jahn, Rudolf Zentel, Frank Rösch

Bioorganic & Medicinal Chemistry Letters 2010, 20, 5454-5458.

DOI: 10.1016/j.bmcl.2010.07.092

Synthesis, Characterization and Preliminary Biological Evaluation of P(HPMA)-b-P(LLA) Copolymers: A New Type of Functional Biocompatible Block Copolymer

Matthias Barz, Florian K. Wolf, Fabiana Canal, Kaloian Koynov, Maria J. Vicent, Holger Frey, Rudolf Zentel

Macromol. Rapid Commun. 2010, 31, 1492–1500.

DOI: 10.1002/marc.201000090

Synthesis and In Vitro Evaluation of Defined HPMA Folate Conjugates: Influence of Aggregation on Folate Receptor (FR) Mediated Cellular Uptake

Matthias Barz, Fabiana Canal, Kaloian Koynov, R. Zentel, and Maria J. Vicent

Biomacromolecules 2010, 11, 2274–2282. DOI: 10.1021/bm100338x

Langmuir-Blodgett Films of Biocompatible Poly(HPMA)- block-poly(lauryl methacrylate) and Poly(HPMA)-random-poly(lauryl methacrylate): Influence of Polymer Structure on Membrane Formation and Stability

Patrick Scheibe, Matthias Barz, Mirjam Hemmelmann, Rudolf Zentel

Langmuir 2010, 26, 5661–5669. DOI: 10.1021/la903725k

The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells

Matthias Barz, Robert Luxenhofer, Rudolf Zentel, Alexander V. Kabanov
Biomaterials 2009, 30, 5682-5690.

DOI: 10.1016/j.biomaterials.2009.06.058

Radioactive Labeling of Defined HPMA-Based Polymeric Structures Using [18F]FETos for In Vivo Imaging by Positron Emission Tomography

Matthias M. Herth, Matthias Barz, Dorothea Moderegger, Mareli Allmeroth, Markus Jahn, Oliver Thews, Rudolf Zentel, Frank Rösch

Biomacromolecules 2009, 10, 1697–1703. DOI: 10.1021/bm8014736

Pathogen-Mimicking MnO Nanoparticles for Selective Activation of the TLR9 Pathway and Imaging of Cancer Cells

Mohammed I. Shukoor, Filipe Natalio, Muhammad Nawaz Tahir, Matthias Wiens, Marco Tarantola, Helen A. Therese, Matthias Barz, Stefan Weber, Maxim Terekhov, Heinz C. Schröder, Werner E. G. Müller, Andreas Janshoff, Patrick Theato, Rudolf Zentel, Laura Maria Schreiber, Wolfgang Tremel

Adv. Funct. Mater. 2009, 19, 3717–3725. DOI: 10.1002/adfm.200900635

Growth of fibrous aggregates of silica nanoparticles: Fibre growth by

mimicking the biogenic silica patterning processes
Muhammad N. Tahir, Filipe Natalio, Rüdiger Berger, Matthias Barz, Patrick Theato, Heinz-Christoph Schröder, Werner E. G. Müller and Wolfgang Tremel

Soft Matter 2009, 5, 3657–3662. DOI: 10.1039/b905178c

Influence of Binding‐Site Density in Wet Bioadhesion

Jijun Wang, Muhammad Nawaz Tahir, Michael Kappl, Wolfgang Tremel, Nadine Metz, Matthias Barz, Patrick Theato, Hans‐Jürgen Butt

Adv. Mater. 2008, 20, 3872–3876. DOI: 10.1002/adma.200801140

From defined reactive diblock copolymers to functional HPMA-based self-assembled nanoaggregates

M Barz, M Tarantola, K Fischer, M Schmidt, R Luxenhofer, A Janshoff, P Theato, R Zentel

Biomacromolecules 2008, 9, 3114-3118. DOI: 10.1021/bm800684b


Barz M, Huesmann D, Birke A, Reuter T, Schäfer O, Heller P.

Thiol-protected amino acid derivatives and uses thereof. 2015,

WO Patent 2015,169,908.

Vicent Docon MJ, Barz M, Canal F, Conejos Sanchez I, Duro Castano A, England R.

Controlled synthesis of polyglutamates with low polydispersity and versatile architectures. 2013,

WO Patent 2013,060,919. (licensed to PTS, Polymer Therapeutic Solutions, Valencia)

Vicent Docon MJ, Barz M, Canal F, Conejos Sanchez I, Duro Castano A, England R.

Controlled synthesis of polyglutamates with low polydispersity and versatile architectures. 2017,

US Patent 9,623,125