Dr. Regina Holm

Dr. Regina Holm


Regina Holm studied Biomedical Chemistry at the University of Twente and JGU Mainz where she obtained her graduate degree in 2014. She conducts her diploma thesis on the synthesis of block copolypept(o)ides and polypept(o)idic star-like polymers. Her current PhD research is focused on the development of stimuli-responsive star-like polymers with functional end groups as nano drug delivery systems.



Institut für Organische Chemie
Johannes Gutenberg-Universität Mainz
Duesbergweg 10-14
55128 Mainz  

+49 6131 39 25468

Research topic

Controlled Synthesis of Polypept(o)idic Architectures: Stimuli Responsive Star-Like Polymers as Novel Nano Drug Delivery Systems


Influence of Riboflavin Targeting on Tumor Accumulation and Internalization of Peptostar Based Drug Delivery Systems

Milita Darguzyte, Regina Holm, Jasmin Baier, Natascha Drude, Jennifer Schultze, Kaloian Koynov, David Schwiertz, Seyed Mohammadali Dadfar, Twan Lammers, Matthias Barz, Fabian Kiessling

Bioconjugate Chem., 2020, 31, 12, 2691-2696

DOI: https://doi.org/10.1021/acs.bioconjchem.0c00593

Facile synthesis of amphiphilic AB3 and A3B miktoarm PeptoMiktoStars

David Schwiertz, Regina Holm, Matthias Barz

Polymer Journal, 2019

DOI: https://doi.org/10.1038/s41428-019-0269-1

Multifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential

Regina Holm, David Schwiertz, Benjamin Weber, Jennifer Schultze, Jasmin Kuhn, Kaloian Koynov, Ulrich Lächelt, Matthias Barz

Macromolecular Bioscience, 2019, 1900152

DOI: //doi.org/10.1002/mabi.201900152

Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization

Olga Schäfer, Dieter Schollmeyer, Alexander Birke, Regina Holm, Kerstin Johann, Christian Muhl, Christine Seidl, Benjamin Weber, Matthias Barz

Tetrahedron Letters 201960, 272–275, DOI: doi.org/10.1016/j.tetlet.2018.12.028

Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers

Regina Holm, Marcel Douverne, Benjamin Weber, Tobias Bauer, Andreas Best, Patrick Ahlers, Kaloian Koynov, Pol Besenius and Matthias Barz

Biomacromolecules, 2018, in press. DOI: 10.1021/acs.biomac.8b01545

Site-Specific DBCO Modification of DEC205 Antibody for Polymer Conjugation

Simone Beck, Jennifer Schultze, Hans-Joachim Räder, Regina Holm, Meike Schinnerer, Matthias Barz, Kaloian Koynov and Rudolf Zentel

Polymers 201810(2), 141; doi:10.3390/polym10020141

Synthesis of Amphiphilic Block Copolypept(o)ides by Bifunctional Initiators: Making PeptoMicelles Redox Sensitive

Regina Holm, Kristina Klinker, Benjamin Weber, Matthias Barz

Macromol. Rapid Commun. 201536, 2083−2091.

DOI: 10.1002/marc.201500402

Synthesis and Characterization of  Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars

Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber, Matthias Barz

Macromol. Biosci. 201717, 1600514. DOI: 10.1002/mabi.201600514

Evaluating chemical ligation techniques for the synthesis of block copolypeptides, polypeptoids and block copolypept(o)ides: a comparative study

Kristina Klinker, Regina Holm, Philipp Heller, Matthias Barz

Polym. Chem. 20156, 4612–4623. DOI: 10.1039/c5py00461f

Tuning the pH-Switch of Supramolecular Polymer Carriers for siRNA to Physiologically Relevant pH

Patrick Ahlers, Hendrik Frisch, Regina Holm, Daniel Spitzer, Matthias Barz, Pol Besenius

Macromol. Biosci. 2017, 1700111. DOI: 10.1002/mabi.201700111