Publications
Cross-Linkable Polyion Complex Micelles from Polypept(o)ide-Based ABC-Triblock Copolymers for siRNA Delivery
Leon Capelôa, Mina Yazdi, Heyang Zhang, Xiaobing Chen, Yu Nie, Ernst Wagner, Ulrich Lächelt, Matthias Barz
Macromol. Rapid Commun., 2022, 2100698
DOI: https://doi.org/10.1002/marc.202100698
The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds
Nils-Jørgen Knudsen Dal, Kerstin Johann, Matthias Barz, Claire Beauvineau, Jens Wohlmann, Federico Fenaroli, Brigitte Gicquel, Gareth Griffiths, Noelia Alonso-Rodriguez
Dis. Model. Mech, 2021, dmm.049147.
DOI: https://doi.org/10.1242/dmm.049147
Radiolabeling of a polypeptide polymer for intratumoral delivery of alpha-particle emitter, 225Ac, and beta- particle emitter, 177Lu
Vladimir Shalgunov, Gokce Engudar, Lennart Bohrmann, Luke Wharton, Keiran Maskell, Kerstin Johann, Matthias Barz, Paul Schaffer, Matthias M. Herth, Valery Radchenko
Nuclear Medicine and Biology, 2022, 15, 11-21, 104-105
DOI: https://doi.org/10.1016/j.nucmedbio.2021.11.001
Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells
Cinja Kappel, Christine Seidl, Carolina Medina-Monatano, Meike Schinnerer, Irina Alberg, Christian Leps, Julian Sohl, Ann-Kathrin Hartmann, Michael Fichter, Michael Kuske, Jenny Schunke, Gabor Kuhn, Ingrid Tubbe, David Paßlick, Dominika Hobernik, Rebekka Bent, Katharina Haas, Evelyn Montermann, Kerstin Walzer, Mustafa Diken, Manfred Schmidt, Rudolf Zentel, Lutz Nuhn, Hansjörg Schild, Stefan Tenzer, Volker Mailänder, Matthias Barz, Matthias Bros, Stephan Grabbe
ACS Nano, 2021, 15, 9, 15191-15209
DOI: https://doi.org/10.1021/acsnano.1c05713
Targeting Cancer Chemotherapy Resistance by Precision Medicine-Driven Nanoparticle-Formulated Cisplatin
Svenja Siemer, Tobias A. Bauer, Paul Scholz, Christina Breder, Federico Fenaroli, Gregory Harms, Dimo Dietrich, Jörn Dietrich, Christine Rosenauer, Matthias Barz, Sven Becker, Sebastian Strieth, Christoph Reinhardt, Torsten Fauth, Jan Hagemann, Roland H. Stauber
ACS Nano, 2021, 15, 11, 18541-18556
DOI: https://doi.org/10.1021/acsnano.1c08632
Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
Kerstin Johann, Toszka Bohn, Fatameh Shahneh, Natascha Luther, Alexander Birke, Henriette Jaurich, Mark Helm, Matthias Klein, Verena K. Raker, Tobias Bopp, Matthias Barz, Christian Becker
Nature Communications, 2021, 12, 5981
DOI: https://doi.org/10.1038/s41467-021-26269-w
Precision Wormlike Nanoadjuvant Governs Potency of Vaccination
Ziyang Sun, Dongdong Qiao, Yi Shi, Matthias Barz, Lixin Liu, Yongming Chen
Nano Lett., 2021, 21, 17, 7236-7243
DOI: https://doi.org/10.1021/acs.nanolett.1c02274
Photocleavable core cross-linked polymeric micelles of polypept(o)ides and ruthenium(II) complexes
Tobias A. Bauer, Jonas Eckrich, Nadine Wiesmann, Felix Kuczelinis, Wen Sun, Xiaolong Zeng, Benjamin Weber, Si Wu, Nicolas Herbert Bings, Sebastian Strieth, Matthias Barz
J. Mater. Chem. B., 2021, Advanced Article
DOI: https://doi.org/10.1039/D1TB01336J
Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages
Tobias A. Bauer, Natalie K. Horvat, Oriana Marques, Sara Chocarro, Christina Mertens, Silvia Colucci, Sascha Schmitt, Luca M. Carrella, Svenja Morsbach, Kaloian Koynov, Federico Fenaroli, Peter Blümler, Michaela Jung, Rocio Sotillo, Matthias W. Hentze, Martina U. Muckenthaler, Matthias Barz
Adv. Healthcare Mater., 2021, 2100385
DOI: https://doi.org/10.1002/adhm.202100385
Delivery of siHIF-1α to Reconstruct Tumor Normoxic Microenvironment for Effective Chemotherapeutic and Photodynamic Anticancer Treatments
Xiaobing Chen, Rongrong Jin, Qian Jiang, Qunjie Bi, Ting He, Xu Song, Matthias Barz, Hua Ai, Xintao Shuai, Yu Nie
Small, 2021, 17, 2100609
DOI: https://doi.org/10.1002/smll.202100609
Secondary Structure-Driven Self-Assembly of Thiol-Reactive Polypept(o)ides
Tobias A. Bauer, Jan Imschweiler, Christian Muhl, Benjamin Weber, Matthias Barz
Biomacromolecules, 2021, 22, 5, 2171-2180
DOI: https://doi.org10.1021/acs.biomac.1c00253
Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics
Svenja Siemer, Dana Westmeier, Matthias Barz, Jonas Eckrich, Desiree Wünsch, Christof Seckert, Christian Thyssen, Oliver Schilling, Mike Hasenberg, Chengfang Pang, Dominic Docter, Shirley K. Knauer, Roland H. Stauber, Sebastian Strieth
Biomaterials., 2020 192, 551-559
DOI: https://doi.org/10.1016/j.biomaterials.2018.11.028
Influence of Riboflavin Targeting on Tumor Accumulation and Internalization of Peptostar Based Drug Delivery Systems
Milita Darguzyte, Regina Holm, Jasmin Baier, Natascha Drude, Jennifer Schultze, Kaloian Koynov, David Schwiertz, Seyed Mohammadali Dadfar, Twan Lammers, Matthias Barz, Fabian Kiessling
Bioconjugate Chem., 2020, 31, 12, 2691-2696
DOI: https://doi.org/10.1021/acs.bioconjchem.0c00593
Racemic S-(ethylsulfonyl)-DL-cysteine N-Carboxyanhydrides Improve Chain Lengths and Monomer Conversion for β-Sheet-Controlled Ring-Opening Polymerization
Tobias A. Bauer, Christian Muhl, Dieter Schollmeyer, Matthias Barz
Macromol. Rapid Commun., 2020, 2000470
DOI: https://doi.org/10.1002/marc.202000470
Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery
Sara S. Nogueira, Anne Schlegel, Konrad Maxeiner, Benjamin Weber, Matthias Barz, Martin A. Schroer, Clement E. Blanchet, Dmitri I. Svergun, Srinivas Ramishetti, Dan Peer, Peter Langguth, Ugur Sahin, Heinrich Haas
ACS Appl. Nano Mater., 2020, 3, 11 , 10634-10645
DOI: https://doi.org/10.1021/acsanm.0c01834
Insight into the synthesis of N-methylated polypeptides
Christian Muhl, Lydia Zengerling, Jonathan Groß, Paul Eckhardt, Till Opatz, Pol Besenius, Matthias Barz
Polym. Chem., 2020, 11 , 6919-6927
DOI: https://doi.org/10.1039/D0PY01055C
A nitroreductase and glutathione responsive nanoplatform for integration of genedelivery and near-infrared fluorescence imaging
Hong Liang, Qunjie Bi, Ao Hu, Xiaobing Chen, Ronrong Jin, Xu Song, Bowen Ke, Matthias Barz, Yu Nie
Chem. Commun., 2020, 56, 6949-6952
DOI: https://doi.org/10.1039/C9CC10071G
Integration of Indocyanine Green Analogs as Near-Infrared Fluorescent Carrier for Precise Imaging-Guided Gene Delivery
Hong Liang, Xiaobing Chen, Rongrong Jin, Bowen Ke, Matthias Barz, Hua Ai, Yu Nie
Small, 2020, 16, 10, 1906538
DOI: https://doi.org/10.1002/smll.201906538
Polymeric Nanoparticles with Neglectable Protein Corona
Irina Alberg, Stefan Kramer, Meike Schinnerer, Qizhi Hu, Christine Seidl, Christian Leps, Natascha Drude, Diana Möckel, Christianne Rijcken, Twan Lammers, Mustafa Diken, Michael Maskos, Svenja Morsbach, Katharina Landfester, Stefan Tenzer, Matthias Barz, Rudolf Zentel.
Small, 2020, 16, 18, 1907574
DOI: https://doi.org/10.1002/smll.201907574
Tetrazine- and trans-cyclooctene-functionalised polypept(o)ides for fast bioorthogonal tetrazine ligation
Kerstin Johann, Dennis Svatunek, Christine Seidl, Silvia Rizzelli, Tobias A. Bauer, Lydia Braun, Kaloian Koynov, Hannes Mikula and Matthias Barz
Polym. Chem., 2020, Advanced Article
DOI: https://doi.org/10.1039/D0PY00375A
Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging
E. Johanna L. Stéen, Jesper T. Jørgensen, Kerstin Johann, Kamilla Nørregaard, Barbara Sohr, Dennis Svatunek, Alexander Birke, Vladimir Shalgunov, Patricia E. Edem, Raffaella Rossin, Christine Seidl, Friederike Schmid, Marc S. Robillard, Jesper L. Kristensen, Hannes Mikula, Matthias Barz, Andreas Kjær, Matthias M. Herth
ACS Nano 2020, 14, 1, 568-584
DOI: https://doi.org/10.1021/acsnano.9b06905
Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle–Cell Interactions
Nils-Jørgen Knudsen Dal, Agnese Kocere, Jens Wohlmann, Simon Van Herck, Tobias A. Bauer, Julien Resseguier, Shahla Bagherifam, Hilde Hyldmo, Matthias Barz, Bruno G. De Geest, Federico Fenaroli
Small, 2020, 1906719
DOI: https://doi.org/10.1002/smll.201906719
Facile synthesis of amphiphilic AB3 and A3B miktoarm PeptoMiktoStars
David Schwiertz, Regina Holm, Matthias Barz
Polymer Journal, 52, 119-132 (2020)
DOI: https://doi.org/10.1038/s41428-019-0269-1
Interactions Between Blood Proteins and Nanoparticles Investigated Using Molecular Dynamics Simulations
Timo Schafer, Christian Muhl, Matthias Barz, Friederike Schmid, Giovanni Settanni
In: W. Nagel, D. Kröner, M. Resch, High Performance Computing in Science and Engineering ' 18. Springer, Cham (2019)
Ligand density on nanoparticles: A parameter with critical impact on nanomedicine
Alaaldin M. Alkilany, Lin Zhu, Horst Weller, Alf Mews, Wolfgang J. Parak, Matthias Barz, Neus Feliu
In Press DOI: /10.1016/j.addr.2019.05.010
Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics
Svenja Siemer1, Dana Westmeier1, Matthias Barz, Jonas Eckrich, Désirée Wünsch, Christof Seckert, Christian Thyssen, Oliver Schilling, Mike Hasenberg, Chengfang Pang, Dominic Doctor, Shirley K. Knauer, Roland H. Stauber, Sebastian Strieth
Biomaterials, 2019, 192, 551-559 DOI: /10.1016/j.biomaterials.2018.11.028
Coordinative Binding of Polymers to Metal–Organic Framework Nanoparticles for Control of Interactions at the Biointerface
ACS Nano, 2019, 13, 4, 3884-3895 DOI: 10.1021/acsnano.8b06287
Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
Inka Negwer, Andreas Best, Meike Schinnerer, Olga Schäfer, Leon Capeloa, Manfred Wagner, Manfred Schmidt, Volker Mailänder, Mark Helm, Matthias Barz, Hans-Jürgen Butt & Kaloian Koynov
Nature Communications, 2018, 9, 5306 DOI: doi.org/10.1038/s41467-018-07755-0
Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization
Olga Schäfer, Dieter Schollmeyer, Alexander Birke, Regina Holm, Kerstin Johann, Christian Muhl, Christine Seidl, Benjamin Weber, Matthias Barz
Tetrahedron Letters, 2018, 60, (3), 272-275
Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers
Regina Holm, Marcel Douverne, Benjamin Weber, Tobias Bauer, Andreas Best, Patrick Ahlers, Kaloian Koynov, Pol Besenius and Matthias Barz
Biomacromolecules, 2019, 20, (1), 375-388 DOI: 10.1021/acs.biomac.8b01545
Poly-Sarcosine and Poly(ethylene-glycol) interactions with proteins investigated using molecular dynamics simulations
Giovanni Settanni, Timo Schäfer, Christian Muhl, Matthias Barz and Friederike Schmid
Computional and Structural Biotechnology Journal, 2018, 16, 543-550. DOI:10.1016/j.csbj.2018.10.012
Poly(S-ethylsulfonyl-l-homocysteine): An α-Helical Polypeptide for Chemoselective Disulfide Formation
Christian Muhl, Olga Schäfer, Tobias Bauer, Hans-Joachim Räder, and Matthias Barz
Macromolecules 2018, 51, (20), 8188-8196 DOI: 10.1021/acs.macromol.8b01442
Secondary Structure-Driven Hydrogelation using Foldable Telechelic Polymer-Peptide Conjugates
R. Otter, N.A. Henke, C. Berac, T. Bauer, M. Barz, S. Seiffert, P. Besenius
Macromol. Rapid Commun. 2018, 39, (17), 1800459. DOI: 10.1002/marc.201800459
Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models
Federico Fenaroli, Urska Repnik, Yitian Xu, Kerstin Johann, Simon Van Herck, Pradip Dey, Frode Miltzov Skjeldal, Dominik M. Frei, Shahla Bagherifam, Agnese Kocere, Rainer Haag, Bruno G. De Geest, Matthias Barz, David G. Russell, and Gareth Griffiths
ACS Nano, 2018, 12 (8), pp 8646–8661. DOI: 10.1021/acsnano.8b04433
Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors
Benjamin Theek, Maike Baues, Felix Gremse, Robert Pola, Michal Pechar, Inka Negwer, Kaloian Koynov, Benjamin Weber, Matthias Barz, Willi Jahnen-Dechent, Gert Storm, Fabian Kiessling, TwanLammers
Journal of Controlled Release, 2018, DOI:10.1016/j.jconrel.2018.05.002
Site-Specific DBCO Modification of DEC205 Antibody for Polymer Conjugation
Simone Beck, Jennifer Schultze, Hans-Joachim Räder, Regina Holm, Meike Schinnerer, Matthias Barz, Kaloian Koynov and Rudolf Zentel
Polymers 2018, 10(2), 141; doi:10.3390/polym10020141
Cooperative Catechol-Functionalized Polypept(o)ide Brushes and Ag Nanoparticles for Combination of Protein Resistance and Antimicrobial Activity on Metal Oxide Surfaces
Jin Yoo, Alexander Birke, Joonwon Kim, Yeongseon Jang, Seuk Young Song, Seungmi Ryu, Byung-Soo Kim, Byung-Gee Kim, Matthias Barz, and Kookheon Char
Biomacromolecules, 2018, DOI: 10.1021/acs.biomac.8b00135
Of Thiols and Disulfides: Methods for Chemoselective Formation of Asymmetric Disulfides in Synthetic Peptides and Polymers
Olga Schäfer and Matthias Barz
Chem. Eur. J., 2018, DOI: 10.1002/chem.201800681
Solution Properties of Polysarcosine: From Absolute and Relative Molar Mass Determinations to Complement Activation
Benjamin Weber, Alexander Birke, Karl Fischer, Manfred Schmidt, and Matthias Barz
Macromolecules, 2018, DOI: 10.1021/acs.macromol.8b00258
Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications
Alexander Birke, Jun Ling, Matthias Barz
Progress in Polymer Science, 2018, in press. doi.org/10.1016/j.progpolymsci.2018.01.002
Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell
Ronja Otter, Kristina Klinker, Daniel Spitzer, Meike Schinnerer, Matthias Barz and Pol Besenius
Chemical Communications, 2018, 54, 401-404. DOI:10.1039/C7CC08127H
From Polymers to Functional Biomaterials
Tanja Weil, Matthias Barz
Macromolecular Bioscience 2017, DOI: 10.1002/mabi.201700307
Combining Orthogonal Reactive Groups in Block Copolymers for Functional Nanoparticle Synthesis in a Single Step
Olga Schäfer, Kristina Klinker, Lydia Braun, David Huesmann, Jennifer Schultze, Kaloian Koynov, and Matthias Barz
Immunomodulatory Therapy of Inflammatory Liver Disease Using Selectin-Binding Glycopolymers
Matthias Bartneck, Christopher T. Schloßer, Matthias Barz, Rudolf Zentel, Christian Trautwein, Twan Lammers, Frank Tacke
ACS Nano 2017, DOI: 10.1021/acsnano.7b04630
PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes
Benjamin Weber, Cinja Kappel, Martin Scherer, Mark Helm, Matthias Bros, Stephan Grabbe, Matthias Barz
Macromol. Biosci. 2017, 1700061. DOI: 10.1002/mabi.201700061
Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines
Philipp Heller, Dominika Hobernik, Ulrich Lächelt, Meike Schinnerer, Benjamin Weber, Manfred Schmidt, Ernst Wagner, Matthias Bros, Matthias Barz
Journal of Controlled Release 2017, 258, 146–160. DOI: 10.1016/j.jconrel.2017.05.012
Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers
Yoanna Tsvetkova, Nataliia Beztsinna, Maike Baues, Dionne Klein, Anne Rix, Susanne K. Golombek, Wa’el Al Rawashdeh, Felix Gremse, Matthias Barz, Kaloian Koynov, Srinivas Banala, Wiltrud Lederle, Twan Lammers, Fabian Kiessling
Nano Lett. 2017, 17, 4665−4674. DOI: 10.1021/acs.nanolett.7b01171
Tuning the pH-Switch of Supramolecular Polymer Carriers for siRNA to Physiologically Relevant pH
Patrick Ahlers, Hendrik Frisch, Regina Holm, Daniel Spitzer, Matthias Barz, Pol Besenius
Macromol. Biosci. 2017, 1700111. DOI: 10.1002/mabi.201700111
Programmable Assembly of Peptide Amphiphile via Noncovalent-to- Covalent Bond Conversion
Kohei Sato, Wei Ji, Liam C. Palmer, Benjamin Weber, Matthias Barz, Samuel I. Stupp
- Am. Chem. Soc. 2017, 139, 8995−9000. DOI: 10.1021/jacs.7b03878
Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures
Kristina Klinker ,Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz
Angew. Chem. Int. Ed. 2017, 56, 9608–9613.
Sekundärstrukturbildung als Triebkraft für die Selbstorganisation reaktiver Polypept(o)ide: Steuerung von Größe, Form und Funktion kernvernetzter Nanostrukturen
Kristina Klinker, Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz
Angew. Chem. 2017 , 129, 9737–9742. DOI: 10.1002/ange.201702624
Influence of Block Ionomer Microstructure on Polyplex Properties: Can Simulations Help to Understand Differences in Transfection Efficiency?
Philipp Heller, Jiajia Zhou, Benjamin Weber, Dominika Hobernik, Matthias Bros, Friederike Schmid, Matthias Barz
Small 2017, 13, 1603694. DOI: 10.1002/smll.201603694
Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles
Matthias Bartneck, Ulf Panzer, Robert Pola, Michal Pechar, Gert Storm,
Nicole Mohr, Matthias Barz, Rudolf Zentel, Fabian Kiessling, Christian Trautwein, Twan Lammers, Frank Tacke
Biomaterials, 2017, 114, 106e120
Synthesis and Characterization of Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars
Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber, Matthias Barz
Macromol. Biosci. 2017, 17, 1600514. DOI: 10.1002/mabi.201600514
Polymeric Selectin Ligands Mimicking Complex Carbohydrates: FromSelectin Binders to Modifiers of Macrophage Migration
Kai E. Moog, Matthias Barz, Matthias Bartneck, Figen Beceren-Braun, Nicole Mohr, Zhuojun Wu, Lydia Braun, Jens Dernedde, Elisa A. Liehn, Frank Tacke, Twan Lammers, Horst Kunz, Rudolf Zentel
Angew. Chem. Int. Ed. 2017, 56, 1416–1421.
Polymere Selectinliganden als komplexe Glykomimetika: von Selectinbindung bis zur Modifizierung der Makrophagenmigration
Kai E. Moog, Matthias Barz, Matthias Bartneck, Figen Beceren-Braun, Nicole Mohr, Zhuojun Wu, Lydia Braun, Jens Dernedde, Elisa A. Liehn, Frank Tacke, Twan Lammers, Horst Kunz, Rudolf Zentel
Angew.Chem. 2017, 129,1438–1443. DOI: 10.1002/ange.201610395
Orthogonally reactive amino acids and end groups in NCA polymerization
David Huesmann, Kristina Klinker, Matthias Barz
Polym. Chem. 2017, 8, 957–971. DOI: 10.1039/C6PY01817C
Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications
Qizhi Hu, Cristianne J.F. Rijcken, Ethlinn van Gaal, Paul Brundel, Hana Kostkova, Tomas Etrych, Benjamin Weber, Matthias Barz, Fabian Kiessling, Jai Prakash, Gert Storm, Wim E. Hennink, Twan Lammers
Rethinking Cysteine Protective Groups: S-Alkylsulfonyl-l-Cysteines for Chemoselective Disulfide Formation
Olga Schäfer, David Huesmann, Christian Muhl, Matthias Barz
Chem. Eur. J. 2016, 22, 18085 –18091. DOI: 10.1002/chem.201604391
Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers
Benjamin Weber, Christine Seidl, David Schwiertz, Martin Scherer, Stefan Bleher, Regine Süss, Matthias Barz
Polymers 2016, 8, 427-440. DOI: 10.3390/polym8120427
Poly(S-ethylsulfonyl-l-cysteines) for Chemoselective Disulfide Formation
Olga Schäfer, David Huesmann, Matthias Barz
Macromolecules 2016, 49, 8146–8153. DOI: 10.1021/acs.macromol.6b02064
Nanoparticles and the immune system: challenges and opportunities
Stephan Grabbe, Katharina Landfester, Detlef Schuppan, Matthias Barz Rudolf Zentel
Nanomedicine 2016, 11, 2621-2624. DOI: 10.2217/nnm-2016-0281
Multidentate Polysarcosine-Based Ligands for Water-Soluble Quantum Dots
Ana Fokina, Kristina Klinker, Lydia Braun, Byeong Guk Jeong, Wan Ki Bae, Matthias Barz, Rudolf Zentel
Macromolecules 2016, 49, 3663−3671.
Complex formation between polyelectrolytes and oppositely charged oligoelectrolytes
Jiajia Zhou, Matthias Barz, Friederike Schmid
The Journal of Chemical Physics 2016, 144, 164902.
Exploring new activating groups for reactive cysteine NCAs
David Huesmann, Olga Schäfer, Lydia Braun, Kristina Klinker, Thomas Reuter, Matthias Barz
Tetrahedron Letters, 2016, 57, 1138–1142.
Bioreducible Poly-l-Lysine–Poly[HPMA] Block Copolymers Obtained by RAFT-Polymerization as Efficient Polyplex-Transfection Reagents
Kristof Tappertzhofen, Simone Beck, Evelyn Montermann, David Huesmann, Matthias Barz, Kaloian Koynov, Matthias Bros, Rudolf Zentel
Macromol. Biosci. 2016, 16, 106–120. DOI: 10.1002/mabi.201500212
Synthesis of Amphiphilic Block Copolypept(o)ides by Bifunctional Initiators: Making PeptoMicelles Redox Sensitive
Regina Holm, Kristina Klinker, Benjamin Weber, Matthias Barz
Macromol. Rapid Commun. 2015, 36, 2083−2091.
Polypept(o)ides: Hybrid Systems Based on Polypeptides and Polypeptoids
Kristina Klinker, Matthias Barz
Macromol. Rapid Commun. 2015, 36, 1943−1957.
Complexity and simplification in the development of nanomedicines
Matthias Barz
Nanomedicine 2015, 10, 3093–3097. DOI: 10.2217/nnm.15.146
Well-defined carbohydrate-based polymers in calcium carbonate crystallization: Influence of stereochemistry in the polymer side chain on polymorphism and morphology
Matthias Barz, Sebastian Götze, Niklas Loges, Timo Schüler, Patrick Theato, Wolfgang Tremel, Rudolf Zentel
European Polymer Journal, 2015, 69, 628–635.
A head-to-head comparison of poly(sarcosine) and poly(ethylene glycol) in peptidic, amphiphilic block copolymers
David Huesmann, Adrian Sevenich, Benjamin Weber, Matthias Barz
Polymer 2015, 67, 240-248. DOI: 10.1016/j.polymer.2015.04.070
Cylindrical Brush Polymers with Polysarcosine Side Chains: A Novel Biocompatible Carrier for Biomedical Applications
Christian Hörtz, Alexander Birke, Leonard Kaps, Sandra Decker, Eva Wächtersbach, Karl Fischer, Detlef Schuppan, Matthias Barz, Manfred Schmidt
Macromolecules 2015, 48, 2074−2086. DOI: 10.1021/ma502497x
Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation
Marina Talelli, Matthias Barz, Cristianne J. F. Rijcken, Fabian Kiessling, Wim E. Hennink, Twan Lammers
Nano Today 2015, 10, 93–117. DOI: 10.1016/j.nantod.2015.01.005
Evaluating chemical ligation techniques for the synthesis of block copolypeptides, polypeptoids and block copolypept(o)ides: a comparative study
Kristina Klinker, Regina Holm, Philipp Heller, Matthias Barz
Polym. Chem. 2015, 6, 4612–4623. DOI: 10.1039/c5py00461f
Directed Interactions of Block Copolypept(o)ides with Mannose-Binding Receptors:PeptoMicelles Targeted to Cells of the InnateImmune System
Philipp Heller, Nicole Mohr, Alexander Birke, Benjamin Weber, Angelika Reske-Kunz, Matthias Bros, Matthias Barz
Macromol. Biosci. 2015, 15, 63–73. DOI: 10.1002/mabi.201400417
Synthesis and Sequential Deprotection of Triblock Copoly-pept(o)ides Using Orthogonal Protective Group Chemistry
Philipp Heller, Benjamin Weber, Alexander Birke, Matthias Barz
Macromol. Rapid Commun. 2015, 36, 38−44.
18F-Radiolabeling, Preliminary Evaluation of Folate-pHPMA Conjugates via PET
Hanno Schieferstein, Annette Kelsch, Achim Reibel, Kaloian Koynov,Matthias Barz, Hans-Georg Buchholz, Nicole Bausbacher, Oliver Thews, Rudolf Zentel, Tobias L. Ross
Macromol. Biosci. 2014, 14, 1396–1405. DOI: 10.1002/mabi.201400200
From Polymers to Nanomedicines: New Materials for Future Vaccines
Philipp Heller, David Huesmann, Martin Scherer, Matthias Barz
Molecular Vaccines. Springer, Cham. 2014, 643–671. DOI:10.1007/978-3-319-00978-0_15
Quo Vadis Nanomedicine
Robert Luxenhofer, Matthias Barz, Michael Schillmeier
Nanomedicine 2014, 9, 2083-2086. DOI: org/10.2217/nnm.14.140
Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells
Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros, Matthias Barz
Macromol. Biosci. 2014, 14, 1380–1395. DOI: 10.1002/mabi.201400167
A Deeper Insight into the Postpolymerization Modification of Polypenta Fluorophenyl Methacrylates to Poly( N -(2-Hydroxy-propyl) Methacrylamide)
Nicole Mohr, Matthias Barz, Romina Forst, Rudolf Zentel
Macromol. Rapid Commun. 2014, 35, 1522−1527.
New Perspectives of HPMA-based Copolymers Derived by Post-Polymerization Modification
Lutz Nuhn, Matthias Barz, Rudolf Zentel
Macromol. Biosci. 2014, 14, 607–618. DOI: 10.1002/mabi.201400028
Revisiting Secondary Structures in NCA Polymerization: Influences on the Analysis of Protected Polylysines
David Huesmann, Alexander Birke, Kristina Klinker, Stephan Türk, Hans Joachim Räder, Matthias Barz
Macromolecules 2014, 47, 928−936. DOI: 10.1021/ma5000392
Polypeptoid-block-polypeptide Copolymers: Synthesis, Characterization, and Application of Amphiphilic Block Copolypept(o)ides in Drug Formulations and Miniemulsion Techniques
Alexander Birke, David Huesmann, Annette Kelsch, Martin Weilbächer, Jing Xie, Matthias Bros, Tobias Bopp, Christian Becker, Katharina Landfester, Matthias Barz
Biomacromolecules 2014, 15, 548−557. DOI: 10.1021/bm401542z
Interaction of N-(2-hydroxypropyl) methacrylamide based homo, random and block copolymers with primary immune cells
Martin Weilbächer, Mareli Allmeroth, Mirjam Hemmelmann, Sandra Ritz, Volker Mailänder, Tobias Bopp, Matthias Barz, Rudolf Zentel, Christian Becker
Journal of Biomedical Nanotechnology 2014, 10, 81-91.
PAA-PAMPS Copolymers as an Efficient Tool to Control CaCO3 Scale Formation
Michael Dietzsch, Matthias Barz, Timo Schüler, Stefanie Klassen, Martin Schreiber, Moritz Susewind, Niklas Loges, Michael Lang, Nadja Hellmann, Monika Fritz, Karl Fischer, Patrick Theato, Angelika Kühnle, Manfred Schmidt, Rudolf Zentel, Wolfgang Tremel
Langmuir 2013, 29, 3080−3088. DOI: 10.1021/la4000044
Synthesis of Maleimide-Functionalyzed HPMA-Copolymers and in vitro Characterization of the aRAGE- and Human Immunoglobulin(huIgG)–Polymer Conjugates
Kristof Tappertzhofen, Verena V. Metz, Mario Hubo, Matthias Barz, Rolf Postina, Helmut Jonuleit, Rudolf Zentel
Macromol. Biosci. 2013, 13, 203–214. DOI: 10.1002/mabi.201200344
A versatile post-polymerization modification method for polyglutamic acid: synthesis of orthogonal reactive polyglutamates and their use in “click chemistry”
Matthias Barz, Aroa Duro-Castano, Maria J. Vicent
Polym. Chem. 2013, 4, 2989-2994. DOI: 10.1039/c3py00189j
A controlled and versatile NCA polymerization method for the synthesis of polypeptides
Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz, María J. Vicent
Polym. Chem. 2013, 4, 3182-3186. DOI: 10.1039/c3py00347g
HPMA Copolymers as Surfactants in the Preparation of Biocompatible Nanoparticles for Biomedical Application
Annette Kelsch, Stephanie Tomcin, Kristin Rausch, Matthias Barz, Volker Mailänder, Manfred Schmidt, Katharina Landfester, Rudolf Zentel
Biomacromolecules 2012, 13, 4179−4187. DOI: 10.1021/bm301453g
P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency
Matthias Barz, Ana Armiñán, Fabiana Canal, Florian Wolf, Kaloian Koynov, Holger Frey, Rudolf Zentel, María J. Vicent
Journal of Controlled Release 2012, 163, 63–74.
CpG-DNA loaded multifunctional MnO nanoshuttles for TLR9-specific cellular cargo delivery, selective immune-activation and MRI
Mohammed I. Shukoor, Filipe Natalio, Muhammad N. Tahir, Matthias Barz, Stefan Weber, Christoph Brochhausen, Rudolf Zentel, Laura M. Schreiber, Jürgen Briegere, Wolfgang Tremel
- Mater. Chem. 2012, 22, 8826-8834. DOI: 10.1039/c2jm16903g
HPMA Based Amphiphilic Copolymers Mediate Central Nervous Effects of Domperidone
Mirjam Hemmelmann, Christiane Knoth, Ulrich Schmitt, Mareli Allmeroth, Dorothea Moderegger, Matthias Barz, Kaloian Koynov, Christoph Hiemke, Frank Rösch, Rudolf Zentel
Macromol. Rapid Commun. 2011, 32, 712–717.
Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics
Matthias Barz, Robert Luxenhofer, Rudolf Zentel, María J. Vicent
Polym. Chem. 2011, 2, 1900-1918. DOI: 10.1039/C0PY00406E
72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging
Matthias M. Herth, Matthias Barz, Markus Jahn, Rudolf Zentel, Frank Rösch
Bioorganic & Medicinal Chemistry Letters 2010, 20, 5454-5458.
Synthesis, Characterization and Preliminary Biological Evaluation of P(HPMA)-b-P(LLA) Copolymers: A New Type of Functional Biocompatible Block Copolymer
Matthias Barz, Florian K. Wolf, Fabiana Canal, Kaloian Koynov, Maria J. Vicent, Holger Frey, Rudolf Zentel
Macromol. Rapid Commun. 2010, 31, 1492–1500.
Synthesis and In Vitro Evaluation of Defined HPMA Folate Conjugates: Influence of Aggregation on Folate Receptor (FR) Mediated Cellular Uptake
Matthias Barz, Fabiana Canal, Kaloian Koynov, R. Zentel, and Maria J. Vicent
Biomacromolecules 2010, 11, 2274–2282. DOI: 10.1021/bm100338x
Langmuir-Blodgett Films of Biocompatible Poly(HPMA)- block-poly(lauryl methacrylate) and Poly(HPMA)-random-poly(lauryl methacrylate): Influence of Polymer Structure on Membrane Formation and Stability
Patrick Scheibe, Matthias Barz, Mirjam Hemmelmann, Rudolf Zentel
Langmuir 2010, 26, 5661–5669. DOI: 10.1021/la903725k
The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells
Matthias Barz, Robert Luxenhofer, Rudolf Zentel, Alexander V. Kabanov
Biomaterials 2009, 30, 5682-5690.
Radioactive Labeling of Defined HPMA-Based Polymeric Structures Using [18F]FETos for In Vivo Imaging by Positron Emission Tomography
Matthias M. Herth, Matthias Barz, Dorothea Moderegger, Mareli Allmeroth, Markus Jahn, Oliver Thews, Rudolf Zentel, Frank Rösch
Biomacromolecules 2009, 10, 1697–1703. DOI: 10.1021/bm8014736
Pathogen-Mimicking MnO Nanoparticles for Selective Activation of the TLR9 Pathway and Imaging of Cancer Cells
Mohammed I. Shukoor, Filipe Natalio, Muhammad Nawaz Tahir, Matthias Wiens, Marco Tarantola, Helen A. Therese, Matthias Barz, Stefan Weber, Maxim Terekhov, Heinz C. Schröder, Werner E. G. Müller, Andreas Janshoff, Patrick Theato, Rudolf Zentel, Laura Maria Schreiber, Wolfgang Tremel
Adv. Funct. Mater. 2009, 19, 3717–3725. DOI: 10.1002/adfm.200900635
Growth of fibrous aggregates of silica nanoparticles: Fibre growth by
mimicking the biogenic silica patterning processes
Muhammad N. Tahir, Filipe Natalio, Rüdiger Berger, Matthias Barz, Patrick Theato, Heinz-Christoph Schröder, Werner E. G. Müller and Wolfgang Tremel
Soft Matter 2009, 5, 3657–3662. DOI: 10.1039/b905178c
Influence of Binding‐Site Density in Wet Bioadhesion
Jijun Wang, Muhammad Nawaz Tahir, Michael Kappl, Wolfgang Tremel, Nadine Metz, Matthias Barz, Patrick Theato, Hans‐Jürgen Butt
Adv. Mater. 2008, 20, 3872–3876. DOI: 10.1002/adma.200801140
From defined reactive diblock copolymers to functional HPMA-based self-assembled nanoaggregates
M Barz, M Tarantola, K Fischer, M Schmidt, R Luxenhofer, A Janshoff, P Theato, R Zentel
Biomacromolecules 2008, 9, 3114-3118. DOI: 10.1021/bm800684b
Patents
Barz M, Huesmann D, Birke A, Reuter T, Schäfer O, Heller P.
Thiol-protected amino acid derivatives and uses thereof. 2015,
WO Patent 2015,169,908.
Vicent Docon MJ, Barz M, Canal F, Conejos Sanchez I, Duro Castano A, England R.
Controlled synthesis of polyglutamates with low polydispersity and versatile architectures. 2013,
WO Patent 2013,060,919. (licensed to PTS, Polymer Therapeutic Solutions, Valencia)
Vicent Docon MJ, Barz M, Canal F, Conejos Sanchez I, Duro Castano A, England R.
Controlled synthesis of polyglutamates with low polydispersity and versatile architectures. 2017,
US Patent 9,623,125