Dr. Olga Schäfer

Dr. Olga Schäfer


Olga Schäfer studied Biomedical Chemistry at the University of Toronto and JGU Mainz where she graduated in 2014. Following her pioneering work on S-ethylthiosulfonyl-L-cysteine in peptide synthesis during her diploma thesis, her PhD research focused on the development of new reactive block copolypept(o)ides and their shape controlled self-assembly into core cross-linked nanostructures for the delivery of therapeutic active components.



Institut für Organische Chemie
Johannes Gutenberg-Universität Mainz
Duesbergweg 10-14
55128 Mainz  

+49 6131 39 25468

research topic

Poly(S-ethylsulfonyl-l-cysteine) in Modular Nanoparticle Synthesis: 
Exploring Key Factors from Disulfide Stabilization, Polypept(o)ide Architectures to Secondary Structures  


Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy

Inka Negwer, Andreas Best, Meike Schinnerer, Olga Schäfer, Leon Capeloa, Manfred Wagner, Manfred Schmidt, Volker Mailänder, Mark Helm, Matthias Barz, Hans-Jürgen Butt & Kaloian Koynov 

Nature Communications, 95306 (2018) DOI: doi.org/10.1038/s41467-018-07755-0

Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization

Olga Schäfer, Dieter Schollmeyer, Alexander Birke, Regina Holm, Kerstin Johann, Christian Muhl, Christine Seidl, Benjamin Weber, Matthias Barz

Tetrahedron Letters 201960, 272–275,  DOI: doi.org/10.1016/j.tetlet.2018.12.028

Poly(S-ethylsulfonyl-l-homocysteine): An α-Helical Polypeptide for Chemoselective Disulfide Formation

Christian MuhlOlga SchäferTobias BauerHans-Joachim Räder and Matthias Barz

Macromolecules 201851 (20), 8188–8196,  DOI: 10.1021/acs.macromol.8b01442

Of Thiols and Disulfides: Methods for Chemoselective Formation of Asymmetric Disulfides in Synthetic Peptides and Polymers

Olga Schäfer and Matthias Barz

Chem. Eur. J. 201824, 12131–12142, DOI: 10.1002/chem.201800681

Combining Orthogonal Reactive Groups in Block Copolymers for Functional Nanoparticle Synthesis in a Single Step

Olga Schäfer, Kristina Klinker, Lydia Braun, David Huesmann, Jennifer Schultze, Kaloian Koynov, and Matthias Barz

ACS Macro Letters 20176, 1140–1145, DOI: 10.1021/acsmacrolett.7b00678

Exploring new activating groups for reactive cysteine NCAs

David Huesmann, Olga Schäfer, Lydia Braun, Kristina Klinker, Thomas Reuter, Matthias Barz

Tetrahedron Letters201657, 1138–1142.

DOI: 10.1016/j.tetlet.2016.01.104

Rethinking Cysteine Protective Groups: S-Alkylsulfonyl-l-Cysteines for Chemoselective Disulfide Formation

Olga Schäfer, David Huesmann, Christian Muhl, Matthias Barz

Chem. Eur. J. 201622, 18085 –18091. DOI: 10.1002/chem.201604391

Poly(S-ethylsulfonyl-l-cysteines) for Chemoselective Disulfide Formation

Olga Schäfer, David Huesmann, Matthias Barz

Macromolecules 201649, 8146–8153. DOI: 10.1021/acs.macromol.6b02064

Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures

Kristina Klinker ,Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz

Angew. Chem. Int. Ed. 201756, 9608–9613.

DOI: 10.1002/anie.201702624

Thiol-protected amino acid derivatives and uses thereof

Barz, D. Huesmann, O. Schäfer, T. Reuter, A. Birke, P. Heller WO2015169908A1, 2014