Leon Capelôa studied biomedical chemistry at the JGU Mainz where he graduated in 2018 (M.Sc.). His PhD project, as a follow-up of his master’s thesis, is focused on the development of polypept(o)ide-based materials to be utilized as delivery systems for therapeutic siRNA. Therefore, his research covers the synthesis and evaluation of new polymeric structures and architectures to complex, stabilize and shield siRNA to enable systemic application.

capeloa@uni-mainz.de

Institut für Organische Chemie
Johannes Gutenberg-Universität Mainz
Duesbergweg 10-14
55128 Mainz

+49 6131 39 25468

Polymer Architectures by Directed Self-Assembly for siRNA Delivery

Cross-Linkable Polyion Complex Micelles from Polypept(o)ide-Based ABC-Triblock Copolymers for siRNA Delivery

Leon Capelôa, Mina Yazdi, Heyang Zhang, Xiaobing Chen, Yu Nie, Ernst Wagner, Ulrich Lächelt, Matthias Barz

Macromol. Rapid Commun., 2022, 2100698

DOI: https://doi.org/10.1002/marc.202100698

Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy

Inka Negwer, Andreas Best, Meike Schinnerer, Olga Schäfer, Leon Capeloa, Manfred Wagner, Manfred Schmidt, Volker Mailänder, Mark Helm, Matthias Barz, Hans-Jürgen Butt & Kaloian Koynov 

Nature Communications, 9, 5306 (2018) DOI: doi.org/10.1038/s41467-018-07755-0

Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures

Kristina Klinker ,Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz

Angew. Chem. Int. Ed. 2017, 56, 9608–9613.

DOI: 10.1002/anie.201702624

Sekundärstrukturbildung als Triebkraft für die Selbstorganisation reaktiver Polypept(o)ide: Steuerung von Größe, Form und Funktion kernvernetzter Nanostrukturen

Kristina Klinker, Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz

Angew. Chem. 2017 , 129, 9737–9742. DOI: 10.1002/ange.201702624