Leon Capelôa
About
Leon Capelôa studied biomedical chemistry at the JGU Mainz where he graduated in 2018 (M.Sc.). His PhD project, as a follow-up of his master’s thesis, is focused on the development of polypept(o)ide-based materials to be utilized as delivery systems for therapeutic siRNA. Therefore, his research covers the synthesis and evaluation of new polymeric structures and architectures to complex, stabilize and shield siRNA to enable systemic application.
Contact
capeloa@uni-mainz.de
Institut für Organische Chemie
Johannes Gutenberg-Universität Mainz
Duesbergweg 10-14
55128 Mainz
+49 6131 39 25468
Research topic
Polymer Architectures by Directed Self-Assembly for siRNA Delivery
Publications
Cross-Linkable Polyion Complex Micelles from Polypept(o)ide-Based ABC-Triblock Copolymers for siRNA Delivery
Leon Capelôa, Mina Yazdi, Heyang Zhang, Xiaobing Chen, Yu Nie, Ernst Wagner, Ulrich Lächelt, Matthias Barz
Macromol. Rapid Commun., 2022, 2100698
Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy
Inka Negwer, Andreas Best, Meike Schinnerer, Olga Schäfer, Leon Capeloa, Manfred Wagner, Manfred Schmidt, Volker Mailänder, Mark Helm, Matthias Barz, Hans-Jürgen Butt & Kaloian Koynov
Nature Communications, 9, 5306 (2018) DOI: doi.org/10.1038/s41467-018-07755-0
Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures
Kristina Klinker ,Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz
Angew. Chem. Int. Ed. 2017, 56, 9608–9613.
Sekundärstrukturbildung als Triebkraft für die Selbstorganisation reaktiver Polypept(o)ide: Steuerung von Größe, Form und Funktion kernvernetzter Nanostrukturen
Kristina Klinker, Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz
Angew. Chem. 2017 , 129, 9737–9742. DOI: 10.1002/ange.201702624