Dr. Philipp Heller

Dr. Philipp Heller

research topic

Peptoplexes as Artificial Viruses for Nucleic Acid Vaccine Delivery


Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines

Philipp Heller, Dominika Hobernik, Ulrich Lächelt, Meike Schinnerer, Benjamin Weber, Manfred Schmidt, Ernst Wagner, Matthias Bros, Matthias Barz

Journal of Controlled Release 2017258, 146–160. DOI: 10.1016/j.jconrel.2017.05.012

Influence of Block Ionomer Microstructure on Polyplex Properties: Can Simulations Help to Understand Differences in Transfection Efficiency?

Philipp Heller, Jiajia Zhou, Benjamin Weber, Dominika Hobernik, Matthias Bros, Friederike Schmid, Matthias Barz

Small 201713, 1603694. DOI: 10.1002/smll.201603694

Synthesis and Characterization of  Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars

Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber, Matthias Barz

Macromol. Biosci. 201717, 1600514. DOI: 10.1002/mabi.201600514

Evaluating chemical ligation techniques for the synthesis of block copolypeptides, polypeptoids and block copolypept(o)ides: a comparative study

Kristina Klinker, Regina Holm, Philipp Heller, Matthias Barz

Polym. Chem. 20156, 4612–4623. DOI: 10.1039/c5py00461f

Directed Interactions of Block Copolypept(o)ides with Mannose-Binding Receptors:PeptoMicelles Targeted to Cells of the InnateImmune System

Philipp Heller, Nicole Mohr, Alexander Birke, Benjamin Weber, Angelika Reske-Kunz, Matthias Bros, Matthias Barz

Macromol. Biosci. 201515, 63–73. DOI: 10.1002/mabi.201400417

Synthesis and Sequential Deprotection of Triblock Copoly-pept(o)ides Using Orthogonal Protective Group Chemistry

Philipp Heller, Benjamin Weber, Alexander Birke, Matthias Barz

Macromol. Rapid Commun. 201536, 38−44.

DOI: 10.1002/marc.201400466

Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells

Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros, Matthias Barz

Macromol. Biosci. 201414, 1380–1395. DOI: 10.1002/mabi.201400167