Dr. Christian Muhl

Dr. Christian Muhl


Christian Muhl studied Chemistry at the University of Massachusetts (Amherst) and JGU Mainz where he finished his Diploma in 2015. His current work is dealing with the synthesis of (Homo)Cystein derivatives for crosslinkable micelles as well as upscaling of NCA synthesis and large scale polymerization of sarcosine based surfactants for various applications.



Institut für Organische Chemie
Johannes Gutenberg-Universität Mainz
Duesbergweg 10-14
55128 Mainz  

+49 6131 39 25468

Research topic

Synthesis of (Homo)Cystein based Blockcopolymers and Polysarcosine containing Amphiphiles


Secondary Structure-Driven Self-Assembly of Thiol-Reactive Polypept(o)ides

Tobias A. Bauer, Jan Imschweiler, Christian Muhl, Benjamin Weber, Matthias Barz

Biomacromolecules, 2021, 22, 5, 2171-2180

DOI: https://doi.org10.1021/acs.biomac.1c00253

Racemic S-(ethylsulfonyl)-DL-cysteine N-Carboxyanhydrides Improve Chain Lengths and Monomer Conversion for β-Sheet-Controlled Ring-Opening Polymerization

Tobias A. Bauer, Christian Muhl, Dieter Schollmeyer, Matthias Barz

Macromol. Rapid Commun., 2020, 2000470

DOI: https://doi.org/10.1002/marc.202000470

Insight into the synthesis of N-methylated polypeptides

Christian Muhl, Lydia Zengerling, Jonathan Groß, Paul Eckhardt, Till Opatz, Pol Besenius, Matthias Barz

Polym. Chem., 2020, 11 , 6919-6927

DOI: https://doi.org/10.1039/D0PY01055C

Poly(Sarcosine) Surface Modification Imparts Stealth-Like Properties to Liposomes

Stefan Bleher, Jonas Buck, Christian Muhl, Sandro Sieber, Sabine Barnert, Dominik Witzigmann, Jörg Huwyler, Matthias Barz, Regine Süss

Small, 2019, 1904716

DOI: https://doi.org/10.1002/smll.201904716


Synthesis and characterization of bisalkylated polysarcosine-based lipopolymers

Christian Muhl, Marcus Conrad, Dennis Unthan, Matthias Barz

European Polymer Journal 120, 2019, 109223

DOI: /doi.org/10.1016/j.eurpolymj.2019.109223

Interactions Between Blood Proteins and Nanoparticles Investigated Using Molecular Dynamics Simulations

Timo Schafer, Christian Muhl, Matthias Barz, Friederike Schmid, Giovanni Settanni

In: W. Nagel, D. Kröner, M. Resch, High Performance Computing in Science and Engineering ' 18. Springer, Cham (2019)

DOI: /10.1007/978-3-030-13325-2_4

Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization

Olga Schäfer, Dieter Schollmeyer, Alexander Birke, Regina Holm, Kerstin Johann, Christian Muhl, Christine Seidl, Benjamin Weber, Matthias Barz

Tetrahedron Letters 201960, 272–275, DOI: doi.org/10.1016/j.tetlet.2018.12.028

Poly-Sarcosine and Poly(ethylene-glycol) interactions with proteins investigated using molecular dynamics simulations

Giovanni SettanniTimo SchäferChristian Muhl, Matthias Barz and Friederike Schmid

Computional and Structural Biotechnology Journal, 2018, in press. DOI:10.1016/j.csbj.2018.10.012

Poly(S-ethylsulfonyl-l-homocysteine): An α-Helical Polypeptide for Chemoselective Disulfide Formation

Christian MuhlOlga SchäferTobias BauerHans-Joachim Räder and Matthias Barz

Macromolecules 201851 (20), 8188–8196, DOI: 10.1021/acs.macromol.8b01442

Rethinking Cysteine Protective Groups: S-Alkylsulfonyl-l-Cysteines for Chemoselective Disulfide Formation

Olga Schäfer, David Huesmann, Christian Muhl, Matthias Barz

Chem. Eur. J. 201622, 18085 –18091. DOI: 10.1002/chem.201604391