Dr. Benjamin Weber

Dr. Benjamin Weber


Benjamin Weber studied chemistry at Northwestern University and JGU Mainz where he graduated in 2014. His research focuses on physicochemical characterization of Polysarcosine as well as of polypept(o)ide-based polymer architectures. The methods range from Langmuir Blodgett trough over multi-angle dynamic and static light scattering to (cryo)TEM. By combining these techniques he wants to investigate a relationship of chemical structure, physico chemical properties and performance of these materials.



Institut für Organische Chemie
Johannes Gutenberg-Universität Mainz
Duesbergweg 10-14
55128 Mainz  

+49 6131 39 25468

research topic

Polysarcosine as a Stealth Polymer in Nanomedicine: 

Investigations on the Solution Properties and Characterization of Polysarcosine-Containing Nanoparticles


Photocleavable core cross-linked polymeric micelles of polypept(o)ides and ruthenium(II) complexes

Tobias A. Bauer, Jonas Eckrich, Nadine Wiesmann, Felix Kuczelinis, Wen Sun, Xiaolong Zeng, Benjamin Weber, Si Wu, Nicolas Herbert Bings, Sebastian Strieth, Matthias Barz

J. Mater. Chem. B., 2021, Advance Article

DOI: https://doi.org/10.1039/D1TB01336J




Secondary Structure-Driven Self-Assembly of Thiol-Reactive Polypept(o)ides

Tobias A. Bauer, Jan Imschweiler, Christian Muhl, Benjamin Weber, Matthias Barz

Biomacromolecules, 2021, 22, 5, 2171-2180

DOI: https://doi.org10.1021/acs.biomac.1c00253

Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery

Sara S. Nogueira, Anne Schlegel, Konrad Maxeiner, Benjamin Weber, Matthias Barz, Martin A. Schroer, Clement E. Blanchet, Dmitri I. Svergun, Srinivas Ramishetti, Dan Peer, Peter Langguth, Ugur Sahin, Heinrich Haas

ACS Appl. Nano Mater., 2020, 3, 11 , 10634-10645

DOI: https://doi.org/10.1021/acsanm.0c01834

Multifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential

Regina Holm, David Schwiertz, Benjamin Weber, Jennifer Schultze, Jasmin Kuhn, Kaloian Koynov, Ulrich Lächelt, Matthias Barz

Macromolecular Bioscience, 2019, 1900152

DOI: //doi.org/10.1002/mabi.201900152

Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization

Olga Schäfer, Dieter Schollmeyer, Alexander Birke, Regina Holm, Kerstin Johann, Christian Muhl, Christine Seidl, Benjamin Weber, Matthias Barz

Tetrahedron Letters 201960, 272–275, DOI: doi.org/10.1016/j.tetlet.2018.12.028

Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers

Regina Holm, Marcel Douverne, Benjamin Weber, Tobias Bauer, Andreas Best, Patrick Ahlers, Kaloian Koynov, Pol Besenius and Matthias Barz

Biomacromolecules, 2018, in press. DOI: 10.1021/acs.biomac.8b01545

Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors

Benjamin TheekMaike BauesFelix Gremse, Robert Pola, Michal PecharInka NegwerKaloian KoynovBenjamin Weber, Matthias Barz, Willi Jahnen-Dechent, Gert Storm, Fabian Kiessling, TwanLammers

Journal of Controlled Release, 2018DOI:10.1016/j.jconrel.2018.05.002

Solution Properties of Polysarcosine: From Absolute and Relative Molar Mass Determinations to Complement Activation

Benjamin Weber, Alexander Birke, Karl Fischer, Manfred Schmidt, and Matthias Barz

Macromolecules, 2018, DOI: 10.1021/acs.macromol.8b00258

PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes

Benjamin Weber, Cinja Kappel, Martin Scherer, Mark Helm, Matthias Bros, Stephan Grabbe, Matthias Barz

Macromol. Biosci. 2017, 1700061. DOI: 10.1002/mabi.201700061

Programmable Assembly of Peptide Amphiphile via Noncovalent-to- Covalent Bond Conversion

Kohei Sato, Wei Ji, Liam C. Palmer, Benjamin Weber, Matthias Barz, Samuel I. Stupp

  1. Am. Chem. Soc. 2017139, 8995−9000. DOI: 10.1021/jacs.7b03878

Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines

Philipp Heller, Dominika Hobernik, Ulrich Lächelt, Meike Schinnerer, Benjamin Weber, Manfred Schmidt, Ernst Wagner, Matthias Bros, Matthias Barz

Journal of Controlled Release 2017258, 146–160. DOI: 10.1016/j.jconrel.2017.05.012

The Influence of Block Ionomer Microstructure on Polyplex Properties: Can Simulations Help to Understand Differences in Transfection Efficiency?

Heller, J. Zhou, B. Weber, D. Hobernik, M. Bros, F. Schmid, M. Barz 
Small 2017, 13: 1603694.

Synthesis and Characterization of  Stimuli-Responsive Star-Like Polypept(o)ides: Introducing Biodegradable PeptoStars

Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H. Stauber, Matthias Barz

Macromol. Biosci. 201717, 1600514. DOI: 10.1002/mabi.201600514

Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications

Qizhi Hu, Cristianne J.F. Rijcken, Ethlinn van Gaal, Paul Brundel, Hana Kostkova, Tomas Etrych, Benjamin Weber, Matthias Barz, Fabian Kiessling, Jai Prakash, Gert Storm, Wim E. Hennink, Twan Lammers

Journal of Controlled Release 2016244, 314–325.

Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers

Benjamin Weber, Christine Seidl, David Schwiertz, Martin Scherer, Stefan Bleher, Regine Süss, Matthias Barz

Polymers 20168, 427-440. DOI: 10.3390/polym8120427

Synthesis and Sequential Deprotection of Triblock Copoly-pept(o)ides Using Orthogonal Protective Group Chemistry

Philipp Heller, Benjamin Weber, Alexander Birke, Matthias Barz

Macromol. Rapid Commun. 201536, 38−44.

DOI: 10.1002/marc.201400466

Directed Interactions of Block Copolypept(o)ides with Mannose-Binding Receptors:PeptoMicelles Targeted to Cells of the InnateImmune System

Philipp Heller, Nicole Mohr, Alexander Birke, Benjamin Weber, Angelika Reske-Kunz, Matthias Bros, Matthias Barz

Macromol. Biosci. 201515, 63–73. DOI: 10.1002/mabi.201400417

A head-to-head comparison of poly(sarcosine) and poly(ethylene glycol) in peptidic, amphiphilic block copolymers

David Huesmann, Adrian Sevenich, Benjamin Weber, Matthias Barz
Polymer 201567, 240-248. DOI: 10.1016/j.polymer.2015.04.070

Synthesis of Amphiphilic Block Copolypept(o)ides by Bifunctional Initiators: Making PeptoMicelles Redox Sensitive

Regina Holm, Kristina Klinker, Benjamin Weber, Matthias Barz

Macromol. Rapid Commun. 201536, 2083−2091.

DOI: 10.1002/marc.201500402

Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells

Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros, Matthias Barz

Macromol. Biosci. 201414, 1380–1395. DOI: 10.1002/mabi.201400167

John B. Matson, Matthew J. Webber, Vibha K. Tamboli, Benjamin Weber and Samuel I. Stupp 
A peptide-based material for therapeutic carbon monoxide delivery 
Soft Matter2012,8: 6689-6692.