Dr. Alexander Birke

Dr. Alexander Birke

Research topic

Synthetic polypept(o)idic Nanomedicines:

Synthesis, Characterization and Application of Polysarcosine containing Copolymer Architectures in pre-targeted Imaging and Tumor Immunotherapy


Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression

Kerstin Johann, Toszka Bohn, Fatameh Shahneh, Natascha Luther, Alexander Birke, Henriette Jaurich, Mark Helm, Matthias Klein, Verena K. Raker, Tobias Bopp, Matthias Barz, Christian Becker

Nature Communications, 2021, 12, 5981

DOI: https://doi.org/10.1038/s41467-021-26269-w

Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization

Olga Schäfer, Dieter Schollmeyer, Alexander Birke, Regina Holm, Kerstin Johann, Christian Muhl, Christine Seidl, Benjamin Weber, Matthias Barz

Tetrahedron Letters 201960, 272–275, DOI: doi.org/10.1016/j.tetlet.2018.12.028

Cooperative Catechol-Functionalized Polypept(o)ide Brushes and Ag Nanoparticles for Combination of Protein Resistance and Antimicrobial Activity on Metal Oxide Surfaces

Jin YooAlexander BirkeJoonwon KimYeongseon JangSeuk Young SongSeungmi RyuByung-Soo KimByung-Gee KimMatthias Barz, and Kookheon Char

Biomacromolecules, 2018, DOI: 10.1021/acs.biomac.8b00135

Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications

Progress in Polymer Science, 2018, in press. doi.org/10.1016/j.progpolymsci.2018.01.002

Cylindrical Brush Polymers with Polysarcosine Side Chains: A Novel Biocompatible Carrier for Biomedical Applications

Christian Hörtz, Alexander Birke, Leonard Kaps, Sandra Decker, Eva Wächtersbach, Karl Fischer, Detlef Schuppan, Matthias Barz, Manfred Schmidt

Macromolecules 201548, 2074−2086. DOI: 10.1021/ma502497x

Directed Interactions of Block Copolypept(o)ides with Mannose-Binding Receptors:PeptoMicelles Targeted to Cells of the InnateImmune System

Philipp Heller, Nicole Mohr, Alexander Birke, Benjamin Weber, Angelika Reske-Kunz, Matthias Bros, Matthias Barz

Macromol. Biosci. 201515, 63–73. DOI: 10.1002/mabi.201400417

Synthesis and Sequential Deprotection of Triblock Copoly-pept(o)ides Using Orthogonal Protective Group Chemistry

Philipp Heller, Benjamin Weber, Alexander Birke, Matthias Barz

Macromol. Rapid Commun. 201536, 38−44.

DOI: 10.1002/marc.201400466

Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells

Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros, Matthias Barz

Macromol. Biosci. 201414, 1380–1395. DOI: 10.1002/mabi.201400167

Revisiting Secondary Structures in NCA Polymerization: Influences on the Analysis of Protected Polylysines

David Huesmann, Alexander Birke, Kristina Klinker, Stephan Türk, Hans Joachim Räder, Matthias Barz

Macromolecules 201447, 928−936. DOI: 10.1021/ma5000392

Polypeptoid-block-polypeptide Copolymers: Synthesis, Characterization, and Application of Amphiphilic Block Copolypept(o)ides in Drug Formulations and Miniemulsion Techniques

Alexander Birke, David Huesmann, Annette Kelsch, Martin Weilbächer, Jing Xie, Matthias Bros, Tobias Bopp, Christian Becker, Katharina Landfester, Matthias Barz

Biomacromolecules 201415, 548−557. DOI: 10.1021/bm401542z

A controlled and versatile NCA polymerization method for the synthesis of polypeptides

Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz, María J. Vicent

Polym. Chem. 20134, 3182-3186. DOI: 10.1039/c3py00347g

The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells

Matthias Barz, Robert Luxenhofer, Rudolf Zentel, Alexander V. Kabanov
Biomaterials 200930, 5682-5690.

DOI: 10.1016/j.biomaterials.2009.06.058