Dr. Alexander Birke
Research topic
Synthetic polypept(o)idic Nanomedicines:
Synthesis, Characterization and Application of Polysarcosine containing Copolymer Architectures in pre-targeted Imaging and Tumor Immunotherapy
Publications
Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
Kerstin Johann, Toszka Bohn, Fatameh Shahneh, Natascha Luther, Alexander Birke, Henriette Jaurich, Mark Helm, Matthias Klein, Verena K. Raker, Tobias Bopp, Matthias Barz, Christian Becker
Nature Communications, 2021, 12, 5981
Investigation of α-amino acid N-carboxyanhydrides by X-ray diffraction for controlled ring-opening polymerization
Olga Schäfer, Dieter Schollmeyer, Alexander Birke, Regina Holm, Kerstin Johann, Christian Muhl, Christine Seidl, Benjamin Weber, Matthias Barz
Tetrahedron Letters 2019, 60, 272–275, DOI: doi.org/10.1016/j.tetlet.2018.12.028
Cooperative Catechol-Functionalized Polypept(o)ide Brushes and Ag Nanoparticles for Combination of Protein Resistance and Antimicrobial Activity on Metal Oxide Surfaces
Jin Yoo, Alexander Birke, Joonwon Kim, Yeongseon Jang, Seuk Young Song, Seungmi Ryu, Byung-Soo Kim, Byung-Gee Kim, Matthias Barz, and Kookheon Char
Biomacromolecules, 2018, DOI: 10.1021/acs.biomac.8b00135
Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications
Alexander Birke, Jun Ling, Matthias Barz
Progress in Polymer Science, 2018, in press. doi.org/10.1016/j.progpolymsci.2018.01.002
Cylindrical Brush Polymers with Polysarcosine Side Chains: A Novel Biocompatible Carrier for Biomedical Applications
Christian Hörtz, Alexander Birke, Leonard Kaps, Sandra Decker, Eva Wächtersbach, Karl Fischer, Detlef Schuppan, Matthias Barz, Manfred Schmidt
Macromolecules 2015, 48, 2074−2086. DOI: 10.1021/ma502497x
Directed Interactions of Block Copolypept(o)ides with Mannose-Binding Receptors:PeptoMicelles Targeted to Cells of the InnateImmune System
Philipp Heller, Nicole Mohr, Alexander Birke, Benjamin Weber, Angelika Reske-Kunz, Matthias Bros, Matthias Barz
Macromol. Biosci. 2015, 15, 63–73. DOI: 10.1002/mabi.201400417
Synthesis and Sequential Deprotection of Triblock Copoly-pept(o)ides Using Orthogonal Protective Group Chemistry
Philipp Heller, Benjamin Weber, Alexander Birke, Matthias Barz
Macromol. Rapid Commun. 2015, 36, 38−44.
Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells
Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros, Matthias Barz
Macromol. Biosci. 2014, 14, 1380–1395. DOI: 10.1002/mabi.201400167
Revisiting Secondary Structures in NCA Polymerization: Influences on the Analysis of Protected Polylysines
David Huesmann, Alexander Birke, Kristina Klinker, Stephan Türk, Hans Joachim Räder, Matthias Barz
Macromolecules 2014, 47, 928−936. DOI: 10.1021/ma5000392
Polypeptoid-block-polypeptide Copolymers: Synthesis, Characterization, and Application of Amphiphilic Block Copolypept(o)ides in Drug Formulations and Miniemulsion Techniques
Alexander Birke, David Huesmann, Annette Kelsch, Martin Weilbächer, Jing Xie, Matthias Bros, Tobias Bopp, Christian Becker, Katharina Landfester, Matthias Barz
Biomacromolecules 2014, 15, 548−557. DOI: 10.1021/bm401542z
A controlled and versatile NCA polymerization method for the synthesis of polypeptides
Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz, María J. Vicent
Polym. Chem. 2013, 4, 3182-3186. DOI: 10.1039/c3py00347g
The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells
Matthias Barz, Robert Luxenhofer, Rudolf Zentel, Alexander V. Kabanov
Biomaterials 2009, 30, 5682-5690.