Our Skills

Amino Acids Synthesis



Development of protective groups for amino acids to enable the straight-forward synthesis of reactive polypeptides, e.g. combining stability in peptide synthesis with chemoselective reactivity in postpolymerization modification techniques.

Polymer Synthesis and Characterization


Development and detailed physicochemical analysis of various polymer architectures, e.g. (multi)block copolymers, brush polymers with homo or block copolymer side chains, star-like polymers or lipopolymers, which combine the polypeptoids polysarcosine with different polypeptide segments.

Synthesis of Functional Nanoparticles


Development of robust, scalable synthetic methods to derive functional nanoparticles with compartmentalized functionalities and precise control over size and shape to tailor particle properties to specific needs in individual applications.

Biomedical Applications



Understanding the interactions of nanoparticles with living organism to develop nanoparticle based tools for diagnosis and therapy of cancer, acute or chronic inflammations, bacterial infections or neurodegenerative diseases.


Latest News

Multifunctional nano-sized drug carriers based on reactive polypept(o)ides

Nano-sized carrier systems find medical application to improve pharmacologic properties of bioactive agents. For many therapeutic approaches, it is important that the carrier system can stably incorporate the cargo during circulation without inducing aggregation, while cargo should ideally only be released after successful cellular uptake. These requirements have thus far only been met by chemistry […]

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Our latest publicatons

Combining Orthogonal Reactive Groups in Block Copolymers for Functional Nanoparticle Synthesis in a Single Step

Olga Schäfer, Kristina Klinker, Lydia Braun, David Huesmann, Jennifer Schultze, Kaloian Koynov, and Matthias Barz, DOI: 10.1021/acsmacrolett.7b00678

Immunomodulatory Therapy of Inflammatory Liver Disease Using Selectin-Binding Glycopolymers

Matthias Bartneck, Christopher T. Schloßer, Matthias Barz, Rudolf Zentel, Christian Trautwein, Twan Lammers, Frank Tacke ACS Nano 2017, DOI: 10.1021/acsnano.7b04630

Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines

Philipp Heller, Dominika Hobernik, Ulrich Lächelt, Meike Schinnerer, Benjamin Weber, Manfred Schmidt, Ernst Wagner, Matthias Bros, Matthias Barz Journal of Controlled Release 2017, 258, 146–160. DOI: 10.1016/j.jconrel.2017.05.012

Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures

Kristina Klinker ,Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz Angew. Chem. Int. Ed. 2017, 56, 9608–9613. DOI: 10.1002/anie.201702624

Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers

Yoanna Tsvetkova, Nataliia Beztsinna, Maike Baues, Dionne Klein, Anne Rix, Susanne K. Golombek, Wa’el Al Rawashdeh, Felix Gremse, Matthias Barz, Kaloian Koynov, Srinivas Banala, Wiltrud Lederle, Twan Lammers, Fabian Kiessling Nano Lett. 2017, 17, 4665−4674. DOI: 10.1021/acs.nanolett.7b01171

Orthogonally reactive amino acids and end groups in NCA polymerization

David Huesmann, Kristina Klinker, Matthias Barz Polym. Chem. 2017, 8, 957–971. DOI: 10.1039/C6PY01817C

Polypept(o)ides: Hybrid Systems Based on Polypeptides and Polypeptoids

Kristina Klinker, Matthias Barz Macromol. Rapid Commun. 2015, 36, 1943−1957. DOI: 10.1002/marc.201500403

Influence of Block Ionomer Microstructure on Polyplex Properties: Can Simulations Help to Understand Differences in Transfection Efficiency?

Philipp Heller, Jiajia Zhou, Benjamin Weber, Dominika Hobernik, Matthias Bros, Friederike Schmid, Matthias Barz Small 2017, 13, 1603694. DOI: 10.1002/smll.201603694
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