Our Skills
Amino Acids Synthesis
Development of protective groups for amino acids to enable the straight-forward synthesis of reactive polypeptides, e.g. combining stability in peptide synthesis with chemoselective reactivity in postpolymerization modification techniques.
Polymer Synthesis and Characterization
Development and detailed physicochemical analysis of various polymer architectures, e.g. (multi)block copolymers, brush polymers with homo or block copolymer side chains, star-like polymers or lipopolymers, which combine the polypeptoids polysarcosine with different polypeptide segments.
Synthesis of Functional Nanoparticles
Development of robust, scalable synthetic methods to derive functional nanoparticles with compartmentalized functionalities and precise control over size and shape to tailor particle properties to specific needs in individual applications.
Biomedical Applications
Understanding the interactions of nanoparticles with living organism to develop nanoparticle based tools for diagnosis and therapy of cancer, acute or chronic inflammations, bacterial infections or neurodegenerative diseases.
Latest News
Open PhD position
The group of Dr. Matthias Barz at the Institute of Organic Chemistry at Johannes Gutenberg University Mainz has an opening for 1 PhD position in synthetic polymer chemistry. The PhD student will join the EU Marie Skłodowska-Curie Innovative Training Network, a consortium of high class academic and private institutions across Europe. The overall aim of […]
Coverpage
Dr. Regina Holm’s latest paper (Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers) is selected for a coverpage in the journal “Biomacromolecules” Congratulation!
Congratulation
We congratulate Dr. Regina Holm for sucessfully defending her PhD. Furthermore we congratulate Marcus Conrad and Gabriela Schäfer for finishing their Bachelor of Science.
Our latest publicatons
Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell

Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications

Combining Orthogonal Reactive Groups in Block Copolymers for Functional Nanoparticle Synthesis in a Single Step

Immunomodulatory Therapy of Inflammatory Liver Disease Using Selectin-Binding Glycopolymers

Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines

Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures

Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers

Orthogonally reactive amino acids and end groups in NCA polymerization

Polypept(o)ides: Hybrid Systems Based on Polypeptides and Polypeptoids

Solution Properties of Polysarcosine: From Absolute and Relative Molar Mass Determinations to Complement Activation
