Dr. David Huesmann

Dr. David Huesmann

research topic

A New Polypept(o)idic Nanoparticle Platform:

From Secondary Structures, Polypept(o)ides and New Cysteine Monomers

publications

Combining Orthogonal Reactive Groups in Block Copolymers for Functional Nanoparticle Synthesis in a Single Step

Olga Schäfer, Kristina Klinker, Lydia Braun, David Huesmann, Jennifer Schultze, Kaloian Koynov, and Matthias Barz

DOI: 10.1021/acsmacrolett.7b00678

Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size,Shape,and Function of Core Cross-Linked Nanostructures

Kristina Klinker ,Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz

Angew. Chem. Int. Ed. 201756, 9608–9613.

DOI: 10.1002/anie.201702624

Sekundärstrukturbildung als Triebkraft für die Selbstorganisation reaktiver Polypept(o)ide: Steuerung von Größe, Form und Funktion kernvernetzter Nanostrukturen

Kristina Klinker, Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz

Angew. Chem. 2017 , 129, 9737–9742. DOI: 10.1002/ange.201702624

Orthogonally reactive amino acids and end groups in NCA polymerization

David Huesmann, Kristina Klinker, Matthias Barz

Polym. Chem. 20178, 957–971. DOI: 10.1039/C6PY01817C

Rethinking Cysteine Protective Groups: S-Alkylsulfonyl-l-Cysteines for Chemoselective Disulfide Formation

Olga Schäfer, David Huesmann, Christian Muhl, Matthias Barz

Chem. Eur. J. 201622, 18085 –18091. DOI: 10.1002/chem.201604391

 
Poly(S-ethylsulfonyl-l-cysteines) for Chemoselective Disulfide Formation

Olga Schäfer, David Huesmann, Matthias Barz

Macromolecules 201649, 8146–8153. DOI: 10.1021/acs.macromol.6b02064

 
Exploring new activating groups for reactive cysteine NCAs

David Huesmann, Olga Schäfer, Lydia Braun, Kristina Klinker, Thomas Reuter, Matthias Barz

Tetrahedron Letters201657, 1138–1142.

DOI: 10.1016/j.tetlet.2016.01.104

Bioreducible Poly-l-Lysine–Poly[HPMA] Block Copolymers Obtained by RAFT-Polymerization as Efficient Polyplex-Transfection Reagents

Kristof Tappertzhofen, Simone Beck, Evelyn Montermann, David Huesmann, Matthias Barz, Kaloian Koynov, Matthias Bros, Rudolf Zentel

Macromol. Biosci. 201616, 106–120. DOI: 10.1002/mabi.201500212

A head-to-head comparison of poly(sarcosine) and poly(ethylene glycol) in peptidic, amphiphilic block copolymers

David Huesmann, Adrian Sevenich, Benjamin Weber, Matthias Barz
Polymer 201567, 240-248. DOI: 10.1016/j.polymer.2015.04.070

Introducing PeptoPlexes: Polylysine-block-Polysarcosine Based Polyplexes for Transfection of HEK 293T Cells

Philipp Heller, Alexander Birke, David Huesmann, Benjamin Weber, Karl Fischer, Angelika Reske-Kunz, Matthias Bros, Matthias Barz

Macromol. Biosci. 201414, 1380–1395. DOI: 10.1002/mabi.201400167

Revisiting Secondary Structures in NCA Polymerization: Influences on the Analysis of Protected Polylysines

David Huesmann, Alexander Birke, Kristina Klinker, Stephan Türk, Hans Joachim Räder, Matthias Barz

Macromolecules 201447, 928−936. DOI: 10.1021/ma5000392

Polypeptoid-block-polypeptide Copolymers: Synthesis, Characterization, and Application of Amphiphilic Block Copolypept(o)ides in Drug Formulations and Miniemulsion Techniques

Alexander Birke, David Huesmann, Annette Kelsch, Martin Weilbächer, Jing Xie, Matthias Bros, Tobias Bopp, Christian Becker, Katharina Landfester, Matthias Barz

Biomacromolecules 201415, 548−557. DOI: 10.1021/bm401542z